1997
DOI: 10.1210/endo.138.3.5024
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Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

Abstract: Leptin, a hormone secreted from white adipose tissue, has been shown to normalize the body weight of ob/ob but not db/db mice as postulated by Coleman in his classical parabiosis experiments. The major effect of leptin is therefore to decrease food intake, thus resulting in a breakdown of fat stores. Recently, we have suggested that leptin plays a role in reproductive physiology based on the observation that leptin treatment but not food restriction rescues the sterility of ob/ob females. In the present commun… Show more

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Cited by 325 publications
(103 citation statements)
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“…Our experiments with pregnant ob/ob mice confirm and extend the observation that leptin is both necessary and sufficient for reproductive system maturation and function (11,17,18,34). We demonstrate that ob/ob females do not need leptin treatment to maintain pregnancy.…”
Section: Fig 3 Leptin Binding Activity In Mouse Serumsupporting
confidence: 85%
“…Our experiments with pregnant ob/ob mice confirm and extend the observation that leptin is both necessary and sufficient for reproductive system maturation and function (11,17,18,34). We demonstrate that ob/ob females do not need leptin treatment to maintain pregnancy.…”
Section: Fig 3 Leptin Binding Activity In Mouse Serumsupporting
confidence: 85%
“…Recent studies have revealed that leptin ameliorates the reproductive malfunction in ob/ob [14, 15, 16] and fasted [7] mice. Leptin administration was found to maintain sexual maturation in female rats with decreased food intake [17]; leptin treatment was determined to advance the onset of puberty in mice [11].…”
Section: Discussionmentioning
confidence: 99%
“…They are not only obese but also fail to achieve puberty and fertility due to hypogonadotrophic hypogonadism, providing evidence for an important role of leptin in reproduction. This association was strengthened by the correction of the infertility in ob/ob mice by the administration of recombinant leptin [65, 66, 67, 68]. The first reports on the effect of leptin administration to normal prepubertal mice described decreased appetite and body weight and the advancement of vaginal opening [69, 70, 71], but the concentration of serum leptin in normal mice did not increase with onset of, and during, sexual maturation [69, 70].…”
Section: Leptin and Pubertymentioning
confidence: 99%