Leptina: un péptido con potencial terapéutico en sujetos obesos

Jiménez, Emilio González; Aguilar-Cordero, María José; García, Catalina Beatriz García; López, Pedro Antonio García; Ferre, J. Álvarez; López, Carlos Alberto Padilla

doi:10.1016/j.endonu.2010.03.018

Cited by 5 publications

(6 citation statements)

References 42 publications

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“…Due to obesity increased influx of white adipose tissue it is suggested that elevated estrogen concentrations may result from an increased conversion of androgens to estrogens by white adipose tissue therefore contributing to the increased plasma estrogen levels seen 76 - 78 . Another key hormone produced by white adipose tissue is leptin, which plays a pivotal role in the regulation of energy intake and expenditure for a review see refs 79 , 80 . Leptin mainly targets receptors in the hypothalamus by counteracting the effects of neuropeptide Y.…”

Section: Interaction Of Adipose Tissue With Hormonal Regulationmentioning

confidence: 99%

Impact of obesity on male fertility, sperm function and molecular composition

et al. 2012

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Male obesity in reproductive-age men has nearly tripled in the past 30 y and coincides with an increase in male infertility worldwide. There is now emerging evidence that male obesity impacts negatively on male reproductive potential not only reducing sperm quality, but in particular altering the physical and molecular structure of germ cells in the testes and ultimately mature sperm. Recent data has shown that male obesity also impairs offspring metabolic and reproductive health suggesting that paternal health cues are transmitted to the next generation with the mediator mostly likely occurring via the sperm. Interestingly the molecular profile of germ cells in the testes and sperm from obese males is altered with changes to epigenetic modifiers. The increasing prevalence of male obesity calls for better public health awareness at the time of conception, with a better understanding of the molecular mechanism involved during spermatogenesis required along with the potential of interventions in reversing these deleterious effects. This review will focus on how male obesity affects fertility and sperm quality with a focus on proposed mechanisms and the potential reversibility of these adverse effects.

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Section: Interaction Of Adipose Tissue With Hormonal Regulationmentioning

confidence: 99%

Impact of obesity on male fertility, sperm function and molecular composition

et al. 2012

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“…Additionally, some studies have shown an increase in Bacteroides levels following weight loss in obese individuals ( Turnbaugh et al, 2006 ; Wexler, 2007 ). Leptin plays a role in regulating the body’s energy balance by reducing food intake, increasing energy expenditure, and inhibiting fat synthesis ( González Jiménez et al, 2010 ). It is suggested that a decrease in leptin levels may be compensated for by an increase in Bacteroidaceae during the re-feeding process after a high-fat diet in E. miletus , thus achieving a balance in energy capacity ( González Jiménez et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

“…Leptin plays a role in regulating the body’s energy balance by reducing food intake, increasing energy expenditure, and inhibiting fat synthesis ( González Jiménez et al, 2010 ). It is suggested that a decrease in leptin levels may be compensated for by an increase in Bacteroidaceae during the re-feeding process after a high-fat diet in E. miletus , thus achieving a balance in energy capacity ( González Jiménez et al, 2010 ). Bacteroides fragilis within the Bacteroides genus can modulate inflammatory factors, stimulate T-cell immunity, and potentially regulate the inflammatory response induced by high-fat diets in E. miletus ( Weiss, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of energy homeostasis regulation at different altitudes in Hengduan Mountain of red-backed vole, Eothenomys miletus, during high-fat diet acclimation: examining gut microbial and physiological interactions

Jia,

Zhang,

Cao

et al. 2024

Front. Microbiol.

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The study aimed to explore the similarities and differences in gut microorganisms and their functions in regulating body mass in Eothenomys miletus across different altitudes in the Hengduan Mountains when exposed to a high-fat diet. Eothenomys miletus specimens were gathered from Dali (DL) and Xianggelila (XGLL) in Yunnan Province, China, and categorized into control, high-fat (1 week of high-fat diet), and re-feeding groups (1 week of high-fat diet followed by 2 weeks of standard food). The analysis utilized 16S rRNA sequencing to assess the diversity and structure of intestinal microbial communities in E. miletus. The investigation focused on the impact of high-fat diet consumption and different altitudes on gut microbial diversity, structure, and physiological markers. Results revealed that a high-fat diet influenced the beta diversity of gut microorganisms in E. miletus, leading to variations in microbial community structure between the two regions with different altitudes. High-fat food significantly affected body mass, white adipose tissue mass, triglycerides, and leptin levels, but not food intake. Specific intestinal microorganisms were observed in the high-fat groups, aiding in food digestion and being enriched in particular flora. In particular, microbial genera like Lactobacillus and Hylemonella were enriched in the high-fat group of DL. The enriched microbiota in the control group was associated with plant polysaccharide and cellulose decomposition. Following a high-fat diet, gut microbiota adapted to support lipid metabolism and energy supply, while upon re-feeding, the focus shifted back to cellulose digestion. These findings suggested that alterations in gut microbial composition, alongside physiological markers, play a vital role in adaptation of E. miletus to the diverse habitats of the Hengduan Mountains at varying altitudes.

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“…La Leptina se une a receptores específicos de superficie celular, el receptor OB-Rb que se encuentra en las neuronas de los núcleos hipotalámicos 7,8 , el núcleo arcuato es regulador del metabolismo energético expresando concentraciones altas de receptores OB-Rb 9,10 , formado por dos poblaciones de neuronas donde interviene la Leptina 11 : la vía orexigenica (inductora del apetito) 12 , formada por neuronas que liberan el Neuropéptido Y (NPY), potente estimulador de la ingesta de alimentos 13 , y por neuronas que producen de AGRP (AGouti-Related Protein); constituyendo parte de la vía anorexigenica (inductora de la saciedad) y comprendiendo neuronas segregativas de propiomelanocortina (POMC) y neuronas liberadoras de CART (Cocaine and Amphetamine-Regulated Transcript) 14 . La actividad de la Leptina es inhibir la vía orexigenica e inducir la vía anorexigenica 3 , áreas fuertemente asociadas con la reducción en la ingesta de alimentos y del metabolismo 15 .…”

Section: Introductionunclassified

Correlación entre Leptina, indicadores antropométricos y parámetros metabólicos en paciente de 5-15 años con sobrepeso-obesidad

Bolívar Enríquez,

Armaza,

Mamani Ortiz

et al. 2023

GMB

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Introducción: la obesidad es un estado patológico caracterizado por una acumulación excesiva de tejido adiposo, la misma secreta adipocinas entre las cuales se encuentra la Leptina que está implicada en importantes funciones metabólicas como el control del apetito y peso corporal. Objetivos: se realizo este estudio de la correlación entre la concentración de Leptina sérica con indicadores antropométricos y parámetros bioquímicos en pacientes entre 5 a 15 años de edad, con sobrepeso u obesidad. Métodos: se efectuó el estudio observacional descriptivo de corte transversal, con 148 pacientes entre 5 y 15 años de edad, se realizaron exámenes bioquímicos para evaluar la concentración de Leptina, Glucosa, Insulina, perfil lipídico e indicadores antropométricos. IMC, %GC y RCE. Resultados: Se determinó correlaciones positivas entre las concentraciones de Leptina sérica con el IMC (75,4; p< 0,000), el (% GC) Porcentaje de grasa corporal (70,7: p< 0,000) y el (RCE) Razón Cintura estatura (75,4; p< 0,000), encontramos que no existe correlación entre la concentración de Leptina y Colesterol Total, por otra parte encontramos correlación negativa inversa con la concentración de Colesterol HDL en el sexo masculino, mientras que los Triglicéridos presentaron una correlación estadísticamente significativa. Por otra parte, no encontramos correlación significativa entre la determinación de la Leptina y la glicemia, por el contrario,la insulina presento una correlación alta estadísticamente significativa (p<0,000).Conclusiones: este estudio muestra la existencia de correlación estadísticamente significativa entre la Leptina sérica con indicadores antropométricos y parámetros bioquímicos en pacientes entre 5 a 15 años de edad, que tienen sobrepeso u obesidad.

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Leptina: un péptido con potencial terapéutico en sujetos obesos

Cited by 5 publications

References 42 publications

Impact of obesity on male fertility, sperm function and molecular composition

Impact of obesity on male fertility, sperm function and molecular composition

Comparative analysis of energy homeostasis regulation at different altitudes in Hengduan Mountain of red-backed vole, Eothenomys miletus, during high-fat diet acclimation: examining gut microbial and physiological interactions

Correlación entre Leptina, indicadores antropométricos y parámetros metabólicos en paciente de 5-15 años con sobrepeso-obesidad

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