Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.

Takahashi, Chika; Numata, Atsushi; Matsumura, Eiko; Minoura, Katsuhiko; Eto, Hiroki; Shingu, Tetsuro; Ito, Tsukasa; Hasegawa, Takeshi

doi:10.7164/antibiotics.47.1242

Cited by 75 publications

(52 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diketopiperazines, a group of cyclic dipeptides showed in recent studies to play a role in the cellcell signaling mechanism in bacteria, so-called "quorum sensing" [18,19]. Besides, many diketopiperazines have significant biological activities (such as cytotoxic, antileukemic, and antineoplasic) or likely act as intermediates of active compounds biosynthesized in the host organisms [20][21][22]. Up to now, diketopiperazines have been mostly found in marine sponges and microorganisms [23,24].…”

Section: Resultsmentioning

confidence: 99%

Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Zheng

Yan

et al. 2005

Appl Biochem Microbiol

View full text Add to dashboard Cite

Among marine bacteria isolated from the cytotoxic sponge Hymeniacidon perleve , one strain NJ6-3-1 classified as Pseudomonas sp. showed both cytotoxic and antimicrobial activities. Fatty acid analysis indicated that the bacterial strain consists mainly of C16:1, C16:0, C18:1, C18:0, C15:0, C14:0. One unusual 9,10-cyclopropane-C17:0 fatty acid and C26:0 also constitute major components, as well as the existence of squalene, the precursor of triterpenoids. The major metabolites in the culture broth were identified as alkaloids, including diketopiperazines and indole compounds, namely 3,6-diisopropylpiperazine-2,5-dione, 3-benzyl-3-isopropylpiperazine-2,5-dione, 3,6-bis-(2-methylpropyl)-piperazine-2,5-dione, indole-3-carboxaldehyde, indole-3-carboxylic acid methyl ester, indole-3-ethanol, and quinazoline-2,4-dione.

show abstract

Section: Resultsmentioning

confidence: 99%

Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Zheng

Yan

et al. 2005

Appl Biochem Microbiol

View full text Add to dashboard Cite

show abstract

“…(4) In addition to halicomycin, Numata and co-workers [84] reported a series of cytotoxic diketopiperazine dimers, leptosins A-F, from the obligate marine fungus Leptosphaeria sp. The producing strain was obtained from the marine alga Sargassum tortile and the six compounds displayed P388 in vitro cytotoxicities in the range of 1.75-8.6 g/ml.…”

Section: Biomedical Activitiesmentioning

confidence: 99%

Marine Microorganisms and Drug Discovery: Current Status and Future Potential

Jensen

Fenical²

2000

Drugs From the Sea

101

View full text Add to dashboard Cite

“…(22a-c) (Takahashi et al 1994). These metabolites that are endowed of cytotoxic, antileukemic and antineoplasic properties, have never been observed in the brown alga the which affords chromenol meroditerpenes (Kikuchi et al 1983;Numata et al 1991).…”

Section: Resultsmentioning

confidence: 99%

Secondary metabolites from marine microorganisms

Kelecom

2002

An. Acad. Bras. Ciênc.

164

View full text Add to dashboard Cite

After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. On the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. Although it is still to early to define tendencies, it may be stated that the metabolites from microorganisms are in most cases quite different from those produced by the invertebrate hosts. Nitrogenated metabolites predominate over acetate derivatives, and terpenes are uncommon. Among the latter, sesquiterpenes, diterpenes and carotenes have been isolated; among nitrogenated metabolites, amides, cyclic peptides and indole alkaloids predominate.

show abstract

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.

Cited by 75 publications

References 10 publications

Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Marine Microorganisms and Drug Discovery: Current Status and Future Potential

Secondary metabolites from marine microorganisms

Contact Info

Product

Resources

About