Leptospira Abortion in Horses

Hodgin, E. C.; Miller, David A.; Lozano, Francisco Javier

doi:10.1177/104063878900100401

Cited by 40 publications

(41 citation statements)

References 6 publications

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“…27,29,30 In one report, hepatic giant cell formation was thought to be due to leptospiral infection.36 Hepatic lesions such as mixed leukocytic infiltration and hepatocellular dissociation have been reported in equine fetuses as due to leptospirosis. 17,36 The lesions in the kidney seem to be specific for leptospiral infections. Nonsuppurative interstitial nephritis and tubular dilation have been reported in leptospiral infection.…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis in Equine Fetuses, Stillborn Foals, and Placentas

et al. 1993

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Abstract. Leptospirosis was diagnosed in 5 1 equine fetuses and 16 stillborn foals with gestational ages from 3% to 11 months. Diagnosis was based on one or more of the following: positive fetal antibody titer, positive fluorescent antibody test, demonstration of spirochetes in kidney and/or placental sections stained by the Warthin-Starry technique, high leptospiral titers in aborting mares, or isolation of Leptospira spp. from fetal organs. Gross lesions were observed in 80.3% of the fetuses, stillborn foals, and placentas. Gross placental lesions included nodular cystic allantoic masses, edema, areas of necrosis of the chorion, and necrotic mucoid exudate coating the chorion. The liver (23 cases) was enlarged, mottled, and pale to yellow. The kidneys (seven cases) were swollen and edematous with pale white radiating streaks in cortex and medulla. Microscopic lesions were observed in 96% of fetuses, stillborn foals, and placentas. Placental lesions consisted of thrombosis, vasculitis, mixed inflammatory cell infiltration of the stroma and villi, cystic adenomatous hyperplasia of allantoic epithelium, and villous necrosis and calcification. Fetal lesions included hepatocellular dissociation, mixed leukocytic infiltration of the portal triads, giant cell hepatopathy, suppurative and nonsuppurative nephritis, pulmonary hemorrhages, pneumonia, and myocarditis. Spirochetes were demonstrated with the Warthin-Starry stain in the allantochorion and/or kidney of 69 of the 7 1 cases. Using the direct fluorescent antibody technique, 56/60 cases tested positively for leptospires. Leptospires were isolated from fetal tissues in 20/42 cases. Sixteen of the isolates were identified by restriction enzyme analysis as Leptospira interrogans serogroup Pomona serovar kennewicki; case Nos. 36 and 41 were serovar grippotyphosa. The other two isolates were not identified.Microagglutination titers against leptospires were demonstrated in the body fluid of 47/67 cases tested and titers ranged from 1 : 50 to greater than 1 : 1,638,400 against Leptospira interrogans serovars pomona, grippotyphosa, copenhageni, hardjo, canicola, and bratislava. Sixty-two of 7 1 aborting mares tested had titers ranging from 200 to greater than 3,276,800. Leptospiral antibody titers in the body fluid and gross and histopathologic lesions did not differ with age, breed, or sex or between fetuses and stillborn foals.

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Section: Discussionmentioning

confidence: 99%

Leptospirosis in Equine Fetuses, Stillborn Foals, and Placentas

et al. 1993

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“…These findings were not surprising because most of the equine abortion studies reported serogroup Pomona (kennewicki) as a cause of abortion. 3,5,6,9,10,15,16,18 Cases 10 and 32 were confirmed by culture as abortions due to infection by L. interrogans serovar grippotyphosa. A third abortion (case 15) was thought to be a result of infection by leptospires in the Grippotyphosa serogroup because the fetal fluid and dam's serum had titers against grippotyphosa.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Serovars of Leptospira Involved in Equine Abortions in Central Kentucky during the 1990 Foaling Season

et al. 1992

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Abstract.A study to determine the prevalence of leptospira-induced abortions in the central Kentucky equine population during the 1990 foaling season and to determine the leptospira serovars responsible was conducted. From July 1, 1989 through June 30, 1990, 32 (4.4%) of 726 submissions (fetuses, stillborn foals, and/or placentas) were diagnosed as leptospirosis by the fluorescent antibody test and/or microscopic agglutination test. Attempts were made to isolate leptospires from the fetal tissues and/or the dam's urine in 31 of these cases. Leptospira interrogans serovar kennewicki was isolated from 11 (35.5%) and serovar grippotyphosa from 2 (6.5%) of the 31 cases. Of 12 cases that were culture negative with serologically positive fetal fluids, 8 had titers against serovar pomona, 1 against bratislava, 1 against grippotyphosa, 1 against hardjo, and 1 against both bratislava and pomona.

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“…La colonización de los túbulos renales proximales de los animales portadores lleva a la eliminación de la bacteria a través de la orina (5). Sin embargo, el hallazgo de ADN por PCR de Leptospira interrogans, serovariedades Bratislava y Pomona, en fluido vaginal de yeguas, sugiere la posibilidad de transmisión sexual (6)(7)(8). Solo se conocen dos registros de detección de ADN por PCR de Leptospira spp.…”

Section: Introductionunclassified

“…en semen de ganado bovino, pequeños rumiantes y porcinos, lo que demuestra una posible transmisión de leptospirosis por contacto sexual (7,8). En equinos, una manifestación común de leptospirosis crónica es la presentación de uveítis recurrente y disminución en el rendimiento atlético; también se presentan fallas reproductivas, abortos debido a la infección intrauterina y muerte fetal (5,11,12), nacidos muertos, mortalidad neonatal y potros débiles al nacimiento (13,11).…”

Section: Introductionunclassified

Determinación molecular de Leptospira spp. en semen y líquido preseminal y estudio serológico de caballos criollos en el departamento de Cundinamarca (Colombia)

Rodrı́guez¹,

Piñeros²,

Prada³

et al. 2017

Rev. Med. Vet.

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El propósito de este estudio fue detectar serológica (prueba de microaglutinación) y molecularmente (el ADN de Leptospira spp. por PCR convencional-reacción de la polimerasa en cadena) la exposición o presencia de Leptospira spp., a partir de muestras de suero sanguíneo, líquido preseminal y semen en caballos reproductores criollos colombianos representativos de esta raza, en 44 criaderos del departamento de Cundinamarca. En Colombia no existen estudios relacionados con la presencia de leptospiras en semen equino, y dentro de los planes sanitarios en esta especie no se vacuna contra esta enfermedad. Se evaluaron muestras de un total de 107 animales, escogidos por muestreo por conveniencia, de las cuales al analizar el suero fueron seroreactivas 35 (32,7 %), correspondientes al serogrupo Leptospira interrogans, serovariedades Canícola, Pomona y Grippotyphosa. Se detectó el DNA de Leptospira spp., por PCR convencional en dos muestras de semen que representaron el 1,9 % del total de muestras. Mediante la técnica de campo oscuro se encontraron en la mayoría de las muestras de líquido preseminal diferentes formas bacterianas, algunas de ellas compatibles con leptospira. También se observaron células de descamación, cristales y uratos. Adicionalmente, no se obtuvo aislamiento de la bacteria en el medio EMJH y no se detectó ADN mediante la técnica de PCR convencional a partir del líquido preseminal.

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Leptospira Abortion in Horses

Cited by 40 publications

References 6 publications

Leptospirosis in Equine Fetuses, Stillborn Foals, and Placentas

Leptospirosis in Equine Fetuses, Stillborn Foals, and Placentas

Prevalence and Serovars of Leptospira Involved in Equine Abortions in Central Kentucky during the 1990 Foaling Season

Determinación molecular de Leptospira spp. en semen y líquido preseminal y estudio serológico de caballos criollos en el departamento de Cundinamarca (Colombia)

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