Leptospirosis among patients presenting with dengue-like illness in Puerto Rico

Bruce, Michael G.; Sanders, Eduard J.; Leake, John A. D.; Zaidel, Oren; Bragg, Sandra L.; Aye, Tin Tin; Shutt, Kathleen A.; Deseda, Carmen; Rigau‐Pérez, José G.; Tappero, Jordan W.; Perkins, Bradley A.; Spiegel, Richard A.; Ashford, David A.

doi:10.1016/j.actatropica.2005.07.001

Cited by 77 publications

(86 citation statements)

References 24 publications

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“…This study suggests, however, that symptoms and laboratory analyses offer minimal distinctions between HV and leptospirosis, requiring specific assays for the latter treatable infection. 21,22 The lack of consistent thrombocytopenia in mild Choclo virus infection is similar to other clinical mimics, such as dengue, malaria, and leptospirosis, but it is distinct from the almost universal thrombocytopenia found in the more severe Sin Nombre virus infection. 23 The high frequency of HV fever and mild HPS in Choclo virus infection contrasted with the high mortality in Andes virus Table 6 Laboratory findings at first clinic visit for all diagnostic categories infection may reflect the highly specific interaction between HV species and the host integrin receptors.…”

Section: Discussionmentioning

confidence: 76%

Hantavirus Fever without Pulmonary Syndrome in Panama

Armién¹,

Pascale²,

Muñoz³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. In Panama, hantavirus pulmonary syndrome (HPS) is caused by Choclo virus, a species phylogenetically related to Andes and Maporal viruses. Up to 60% of the population has been positive for specific serum antibody in community-based surveys, but mortality is very uncommon. In four western Panama clinics, we tested individuals presenting with a severe febrile prodrome for acute hantavirus (HV) infection by immunoglobulin M enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction as well as clinically similar infections, such as dengue and leptospirosis. From 2006 to 2009, at least 21% of 117 patients diagnosed with HV infection had HV Fever (HF) with no evidence of pulmonary edema (no respiratory distress or radiographic lung infiltrates), and 44% of patients had very mild HPS (radiographic pulmonary edema but no respiratory insufficiency). HV infection caused by Choclo virus in Panama presents often as HF, which contrasts with HV in the Americas but is consistent with the high seroprevalence in endemic regions.

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Section: Discussionmentioning

confidence: 76%

Hantavirus Fever without Pulmonary Syndrome in Panama

Armién¹,

Pascale²,

Muñoz³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…The therapeutic options and prognoses of patients can be similarly complex (22). Some studies have shown that co-infection with dengue and leptospirosis is possible, which re-emphasizes the need for specific diagnostics for both diseases (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

et al. 2015

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“…For the differential diagnosis (Bruce et al, 2005;Wilder-amith et al, 2004), the physician -in given cases -may request a hemoculture, thick film, study of the cerebrospinal fluid (cytochemical and bacteriological), and other more specific tests. the radiological studies of the thorax and the abdominal ultrasonography are very useful in the hemorrhagic dengue, as well as the electrocardiogram and the echocardiogram if a myocardial dysfunction is suspected.…”

Section: Tests In Clinical Laboratories and Tests By Imagesmentioning

confidence: 99%

Dengue

Torres

2008

Estud. av.

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El dengue es hoy la más importante arbovirosis, por su gran carga de enfermedad e implicaciones sociales. El mosquito Aedes aegypti, su principal transmisor convive con el hombre en su hábitat domestico y peridoméstico. El cuadro clínico es de fiebre, cefalea, dolor retroocular, dolores corporales, exantema y mucho decaimiento. El enfermo puede empeorar súbitamente y presentar choque por dengue, con grandes hemorragias digestivas y elevada mortalidad. No existe droga antiviral, pero la muerte puede evitarse mediante la infusión intravenosa precoz de soluciones cristaloides. Algunos candidatos vacunales están actualmente en ensayo clínico. La prevención depende del control del vector, mediante educación sanitaria y reordenamiento ambiental.

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Leptospirosis among patients presenting with dengue-like illness in Puerto Rico

Cited by 77 publications

References 24 publications

Hantavirus Fever without Pulmonary Syndrome in Panama

Hantavirus Fever without Pulmonary Syndrome in Panama

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

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