Les canules nasales à haut débit comme traitement de première intention de l’insuffisance respiratoire hypoxémique associée à la COVID-19 : une étude de cohorte historique monocentrique.

Schwartz, Blair Carl; Jayaraman, Dev; Yang, Stephen Su; Wong, Evan G.; Lipes, Jed; Dial, Sandra

doi:10.1007/s12630-022-02218-z

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…This is in line with literature, where HFNO use has been shown to be effectively used in the wards in several studies, thus, reducing both the need for mechanical ventilation as well as transfers to the ICU for patients that could be treated with HFNO in the ward [4,18,24,25]. Importantly, HFNO use was not shown to increase COVID-19 infections in healthcare personnel when used both in an ICU and in a ward setting [4,26].…”

Section: Discussionsupporting

confidence: 88%

High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study

IOANNOU,

AKOUMIANAKIS,

FILIPPATOS

et al. 2022

Kurume Med. J.

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High-flow nasal oxygen (HFNO) and prone positioning may improve outcomes of coronavirus disease 2019 patients treated in the intensive care unit (ICU). The aim of this study was to describe outcomes following the timely application of HFNO and prone positioning in COVID-19 patients treated in a ward setting. Methods: The study included 89 prospectively recruited subjects at the COVID-19 ward unit of the University Hospital of Heraklion, Greece, between March and December 2020. Results: Seventy-four (83%) of the 89 subjects in the study had severe COVID-19. Of those, 33 (45%) required HFNO treatment and prone positioning and 15 (45%) were transferred to the ICU, with 4 of them being intubated. Severe COVID-19 and HFNO needs were associated with an increased pneumonia severity index (PSI) score on admission and a worse PaO 2 /FiO 2 ratio. In multivariate analysis, PSI was the only independent predictor of subsequent HFNO needs (OR=1.022). Overall intubation and mortality rates were 5.6% and 3.4%, respectively. Conclusion:This study shows that for patients with severe COVID-19 hospitalized in medical wards, standard COVID-19 treatment, along with the timely utilization of HFNO and prone positioning, resulted in excellent outcomes with fewer ICU admission rates.

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Section: Discussionsupporting

confidence: 88%

High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study

IOANNOU,

AKOUMIANAKIS,

FILIPPATOS

et al. 2022

Kurume Med. J.

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“…Orotracheal intubation rate was analysed in 22 studies [ 29 – 31 , 33 – 38 , 43 , 45 , 46 , 48 , 50 , 53 , 54 , 56 – 61 ], and in 12 of these studies, HFNC was associated with a reduction of orotracheal intubations. From these, five studies revealed that intubation rate was lower among those who were successfully managed with HFNC compared to those who failed it [ 29 , 37 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of high-flow nasal cannula therapy on clinical outcomes in adults with COVID-19: A systematic review

Arruda¹,

Kieling²,

Melo-Diaz³

2023

Can J Respir Ther

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Introduction/Background Coronavirus disease 2019 (COVID-19) has high transmissibility and mortality rates. High-flow nasal cannula therapy (HFNC) might reduce the need for orotracheal intubation, easing the burden on the health system caused by COVID-19. The objective of the present study was to examine the effectiveness of HFNC in adult patients hospitalized with COVID-19. Specifically, the present study explores the effects of HFNC on rates of mortality, intubation and intensive care units (ICU) length of stay. The present study also seeks to define predictors of success and failure of HFNC. Methods A systematic literature search was conducted in the PubMed, EMBASE and SCOPUS databases, and the study was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Study quality was assessed using the National Heart, Lung, and Blood Institute’s Study Quality Assessment Tools. Results The search identified 1,476 unique titles; 95 articles received full-text reviews and 40 studies were included in this review. HFNC was associated with a reduction in the rate of orotracheal intubation, notably when compared to conventional oxygen therapy. Studies reported inconsistency in whether HFNC reduced ICU length of stay or mortality rates. Among the predictors of HFNC failure/success, a ratio of oxygen saturation index of approximately 5 or more was associated with HFNC success. Conclusion In adult patients hospitalized with COVID-19, HFNC may prove effective in reducing the rate of orotracheal intubation. The ratio of the oxygen saturation index was the parameter most examined as a predictor of HFNC success. Low-level research designs, inherent study weaknesses and inconsistent findings made it impossible to conclude whether HFNC reduces ICU length of stay or mortality. Future studies should employ higher level research designs.

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Les canules nasales à haut débit comme traitement de première intention de l’insuffisance respiratoire hypoxémique associée à la COVID-19 : une étude de cohorte historique monocentrique.

Abstract: Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Cited by 2 publications

References 25 publications

High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study

High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in Greek Patients: A Prospective Observational Study

Effectiveness of high-flow nasal cannula therapy on clinical outcomes in adults with COVID-19: A systematic review

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