Les courbes ROC en biologie médicale

Morín, Vera; Morin, JF; Mercier, Mariette; Moineau, MP; Jp, Codet

doi:10.1016/s0923-2532(98)80016-1

Cited by 8 publications

(1 citation statement)

References 8 publications

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“…It must be noticed that comparison of under the curve areas may be of limited power, but remains reliable when the curves have similar shapes, as in this study [16].…”

Section: Resultsmentioning

confidence: 63%

Efficiency of Ultrasound and Biochemical Markers for Down’s Syndrome Risk Screening

Benattar

Audibert²,

Taieb³

et al. 1999

Fetal Diagn Ther

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Objective: To evaluate the sequential combination of ultrasound screening for fetal aneuploidy at 11–14 weeks with maternal biochemistry at 12–14 and 15–18 weeks of gestation. Methods: A prospective study including 1,656 women, with a singleton pregnancy booked before 13 weeks of gestation. Nuchal translucency (NT) thickness was measured by transabdominal ultrasound examination. α-Fetoprotein, free βhCG and hCG were measured by immunoradiometric (12–14 weeks) or immunometric (15–18 weeks) assays. Derived risks were then calculated. Cutoff risks were chosen first arbitrarily at 1/250 and then adjusted for a 5% false-positive rate. Results: Seven fetal aneuploidies were diagnosed, including 5 Down’s syndromes, 1 trisomy 18 and 1 triploidy. Three Down’s syndromes had concordant high risk with the 3 screenings. One was at low risk with NT, and another was at low risk by maternal serum screening, but sequential combination of screenings led to a 100% detection rate with cutoffs of 1/240, 1/160 and 1/250 for NT, first- and second-trimester biochemistry, respectively (i.e. for a cutoff adjusted for a 5% false-positive rate). Conclusion: This preliminary study suggests a benefit in combining maternal age-related risk together with NT and biochemical markers in the first or the second trimester. The algorithm combining these risks needs to be established in a wide population.

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“…It must be noticed that comparison of under the curve areas may be of limited power, but remains reliable when the curves have similar shapes, as in this study [16].…”

Section: Resultsmentioning

confidence: 63%

Efficiency of Ultrasound and Biochemical Markers for Down’s Syndrome Risk Screening

Benattar

Audibert²,

Taieb³

et al. 1999

Fetal Diagn Ther

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East of the Andes: The genetic profile of the Peruvian Amazon populations

Corcia

Mellado

Francia

et al. 2017

American J Phys Anthropol

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The Peruvian Amazon is home to an array of populations with differential rates of genetic exchanges with their neighbors and with the Andean people, depending on their peculiar demographic histories. We highlighted some successful Y chromosome lineages expansions originated in Peru during the pre-Columbian history which involved both Andeans and Amazon Arawak people, showing that at least a part of the Amazon rainforest did not remain isolated from those exchanges.

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