Occupational stress presents a major public health problem. It is the subject of many works in Morocco and in the world. Our work focuses on the study of stress resistance among nurses and physicians working in services at Ibn Sina Hospital in Rabat, Morocco. The aim of this study is to analyze the relationship between resistance status, burnout and level of psychological distress. A self-questionnaire is provided to all respondents. It includes questions about socio-demographic and professional, clinical, also neuropsychological tests such as the stress resistance test (CTRS), the burnout scale (MBI) and the general health questionnaire (GHQ12). This study shows that 42% of nurses and physicians have a high level of emotional exhaustion, high level of depersonalization affects 49% of nurses and physicians and subjects with low professional achievement account for 67% and 54% of nurses and physicians suffer from psychological distress. The stress test reveals that 88% of subjects have a low or moderate level of stress resistance and only 12% have good resistance. Thus, our study sheds new light on the understanding of stress at work by using new measurement and evaluation methods such as TRS, with the aim of reducing or eliminating the impact of occupational stress in hospitals.