Les différentes alternatives d’anticoagulation au couple héparine/protamine en chirurgie cardiaque sous circulation extra-corporelle

Pilot validation of an individualised pharmacokinetic algorithm for protamine dosing after systemic heparinisation for cardiopulmonary bypass

“…Globally, unfractionated heparin remains the most widely used agent for this purpose. 1,2 It is found on the WHO Model List of Essential Medications, reflecting affordability, predictable pharmacokinetics and the availability of an effective reversal agent: protamine. However, where heparin is lauded for its ease of use, the administration of protamine is undertaken cautiously, due to its well-known side-effect profile.…”