Les facteurs pronostiques du cancer du rein

Letang, N.; Cabaniols, L.; Pouessel, Damien; Robert, M; Iborra, F.; Culine, S.; Jj, Patard; Guiter, J; Thuret, Rodolphe

doi:10.1684/bdc.2009.0845

Cited by 4 publications

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“…Pathologic classification, TNM stage, and clinical opinion of RCC are known as important factors in the patient's prognosis [10]. Additionally, various factors in prognosis have been studied recently, such as the expression of claudin and its value as a prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Expression of Claudin-1 and -7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance

et al. 2011

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PurposeWe investigated the correlations between the expression of claudin-1 and claudin-7 in clear cell renal cell carcinoma (clear cell RCC) and clinical parameters.Materials and MethodsThe subjects of this study were 119 patients with confirmed clear cell RCC between January 2000 and December 2007. Their RCC tissues were immunohistochemically stained for claudin-1 and claudin-7. The correlations between the expression of claudin and parameters such as sex, age, body mass index (BMI), tumor size, TNM stage, Furhman nuclear grade, postoperative distant metastasis, and cancer-specific survival were analyzed.ResultsAmong the total 119 subjects, claudin-1 was expressed in 18 (15.1%) and claudin- 7 in 31 (26.1%). Claudin-1 was expressed in patients who were older (p=0.007), who had a greater tumor size (p=0.001), who had a higher pathologic T stage (p=0.009), who had preoperative distant metastasis (p=0.035), and who had a higher Furhman nuclear grade (p=0.004). Claudin-7 was expressed only in patients who had a higher Furhman nuclear grade (p=0.031). The risk of postoperative distant metastasis was associated with the expression of claudin-1 (p<0.001) but not with the expression of claudin-7 (p=0.668). The expression of claudin-1 and -7 was not associated with cancer-specific survival (p>0.05).ConclusionsIn clear cell RCC, claudin-1 was expressed in patients who were older and who had a greater tumor size, who had higher T or M stages, and who had a higher Furhman nuclear grade. The expression of claudin-1 was associated with a higher risk of postoperative distant metastasis.

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Section: Discussionmentioning

confidence: 99%