Les follicules polyovocytaires

Reynaud, Karine; Halter, Sabine; Tahir, Zekai; Thoumire, Sandra; Chebrout, Martine; Chastant-Maillard, Sylvie

doi:10.1016/j.gyobfe.2010.04.008

Cited by 14 publications

(4 citation statements)

References 25 publications

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“…Furthermore, the frequency of MOFs differs among species or individuals, with possums showing high incidence of MOFs (e.g. approximately 100 oocytes per follicle), and almost 70% of female dogs having more than one MOF in their ovary [30]. In rabbit ovaries, MOFs were also found in all phases of folliculogenesis, from primary to preovulatory follicles [17].…”

Section: Discussionmentioning

confidence: 99%

Unique morphological characteristics in the ovary of cotton rat (<i>Sigmodon hispidus</i>)

Islam

Ichii

Nakamura

et al. 2020

Journal of Reproduction and Development

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Cotton rats (Sigmodon hispidus, CRs) are commonly used as animal models in biomedical research. However, the reproductive characteristics and ovarian development in the CRs has not been widely investigated. We have previously shown that female CRs, in particular, show several unique phenotypes associated with the urogenital system, such as chronic kidney disease and pyometra. Our investigation revealed unique morphologies in CR ovaries, particularly in oocytes. Cotton rat ovaries at 6-8 weeks of age were obtained from the Hokkaido Institute of Public Health, and their sections analyzed by light microscopy and transmission electron microscopy. Although the general histology and folliculogenesis of CR ovaries were similar to those of other experimental rodents, multi-oocyte follicles (MOFs) and double nucleated oocytes (DNOs) were also observed. Although MOFs were found at all stages of follicular development, a greater frequency of MOFs was observed in the primary and secondary stages. However, DNOs tended to be frequently observed in primordial follicles. Almost all MOF oocytes and a few DNOs possessed a clear zona pellucida, expressed DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 and Forkhead box protein 2, a representative marker of oocytes and follicular epithelial cells. Thus, our investigations revealed the unique phenotypes of the CR ovary. As MOFs and DNOs are occasionally observed in human patients with infertility, the CR would be a useful animal model to study for gaining a better understanding of folliculogenesis and oocytogenesis, as well as their abnormalities in humans and other animals.

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Section: Discussionmentioning

confidence: 99%

Unique morphological characteristics in the ovary of cotton rat (<i>Sigmodon hispidus</i>)

Islam

Ichii

Nakamura

et al. 2020

Journal of Reproduction and Development

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“…In polyovular follicles, the quality of the various oocytes is often heterogeneous. Numerous authors reported that polyovular follicles are able to reach ovulation and ovulate (Reynaud et al 2010), but their destiny in agoutis remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Estimation, morphometry and ultrastructure of ovarian preantral follicle population in agouti (Dasyprocta leporina)

et al. 2018

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The aim of this study was to characterize the preantral ovarian follicular population in agoutis (D. leporina) by estimating the number of follicles at each developmental category, and also describe the morphometry and the specific features of the follicle and the oocyte by using light and transmission electron microscopy. The length of each ovary was measured using a caliper rule, longitudinally sectioned into two halves and both were immediately fixed to perform the estimation of follicular population and ultrastructural analysis. The mean (±S.E.M.) population of follicular per pair of ovary was estimated at 4419.8±532.26 and 5397.52±574.91 for right and left ovaries, respectively, but no differences were observed between them. The diameters for follicles, oocyte and nuclei were: 18.62±3.40μm, 12.28±2.37μm and 6.10±0.93μm for primordial, 23.75±5.70μm, 14.22±3.00μm and 6.70±1.24μm for primary and 88.55±17.61μm, 52.85±17.56μm and 22.33±17.61μm for secondary follicles, respectively. The most of the follicles found belonged to the primordial category (86.63%), followed by primary (13.01%) and secondary (0.35%) one. Additionally, polyovular follicles were observed in all the animals and they represented 7.51% of the total follicles counted. The ultrastructural analysis showed that the oocyte presented a central and regular nuclei, displaying a homogenous mass. Among the organelles, the mitochondria were the most abundant and the oocyte Golgi apparatus was rarely observed. In conclusion, this work shows for the first time the characterization of the population of preantral follicles in the ovary of Dasyprocta leporina. Those information will be useful for further development and adaptation of biotechniques such as germplasm cryopreservation and in vitro gametes manipulation.

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“…The percentage of poly-ovular follicles is quite variable between species and between individuals within species. It is particularly high in the ovaries of cats (up to 4% of follicles) and dogs (up to 14% of follicles), each poly-ovular follicle containing between 2 and 17 oocytes [ 13 , 14 ]. In humans, poly-ovular follicles and polynuclear oocytes are found in 98% of 18- to 52-year-old women and represent between 0.06% and 2.44% of the total follicular population of the ovary [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…In poly-ovular follicles, the quality of the oocytes is often heterogeneous. Some poly-ovular follicles are able to ovulate but generally, at most a single oocyte is fertilized [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Crazy Ovary

Monget

McNatty

Monniaux

2021

Genes

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From fetal life until senescence, the ovary is an extremely active tissue undergoing continuous structural and functional changes. These ever-changing events are best summarized by a quotation attributed to Plato when describing motion in space and time—‘nothing ever is but is always becoming…’. With respect to the ovary, these changes include, at the beginning, the processes of follicular formation and thereafter those of follicular growth and atresia, steroidogenesis, oocyte maturation, and decisions relating to the number of mature oocytes that are ovulated for fertilization and the role of the corpus luteum. The aims of this review are to offer some examples of these complex and hitherto processes. The ones herein have been elucidated from studies undertaken in vitro or from normal in vivo events, natural genetic mutations or after experimental inactivation of gene function. Specifically, this review offers insights concerning the initiation of follicular growth, pathologies relating to poly-ovular follicles, the consequences of premature loss of germ cells or oocytes loss, the roles of AMH (anti-Müllerian hormone) and BMP (bone morphogenetic protein) genes in regulating follicular growth and ovulation rate together with species differences in maintaining luteal function during pregnancy. Collectively, the evidence suggests that the oocyte is a key organizer of normal ovarian function. It has been shown to influence the phenotype of the adjacent somatic cells, the growth and maturation of the follicle, and to determine the ovulation rate. When germ cells or oocytes are lost prematurely, the ovary becomes disorganized and a wide range of pathologies may arise.

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Les follicules polyovocytaires

Cited by 14 publications

References 25 publications

Unique morphological characteristics in the ovary of cotton rat (<i>Sigmodon hispidus</i>)

Unique morphological characteristics in the ovary of cotton rat (<i>Sigmodon hispidus</i>)

Estimation, morphometry and ultrastructure of ovarian preantral follicle population in agouti (Dasyprocta leporina)

The Crazy Ovary

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