Natural catchments are likely to show the existence of knickpoints in their river networks. The origin and genesis of the knickpoints can be manifold, considering that the present morphology is the result of the interactions of different factors such as tectonic movements, quaternary glaciations, river captures, variable lithology, and base-level changes. We analyzed the longitudinal profiles of the river channels in the Stura di Demonte Valley (Maritime Alps) to identify the knickpoints of such an alpine setting and to characterize their origins. The distribution and the geometry of stream profiles were used to identify the possible causes of the changes in stream gradients and to define zones with genetically linked knickpoints. Knickpoints are key geomorphological features for reconstructing the evolution of fluvial dissected basins, when the different perturbing factors affecting the ideally graded fluvial system have been detected. This study shows that even in a regionally small area, perturbations of river profiles are caused by multiple factors. Thus, attributing (automatically)-extracted knickpoints solely to one factor, can potentially lead to incomplete interpretations of catchment evolution.Geosciences 2018, 8, 443 2 of 20 same drainage system, pointing out the complexity of this issue. Furthermore, a distinction should be made between knickpoints caused by regional factors and those determined by local perturbation agents. While the former usually inherit information on tectonic uplift or climatic changes, the latter may be related to local fluvial captures, lithological control, and landslides. The detection, dynamics, and influence of the knickpoints in landscape evolution have been investigated in recent studies [17][18][19][20][21], which emphasize that mono-causal knickpoints in river networks are generally well understood, but that in the majority of natural catchments multi-causal knickzone systems are possible.The aim of this study is to identify the prevailing processes active in generating knickpoints in such a natural, alpine basin, which is affected by tectonic uplift and Pleistocene glaciation and is sensitive to base-level changes at the transition between mountain front and foreland. We chose the Stura River basin (Figure 1) because its morphology was shaped by tectonics, Quaternary glacial phases, variable lithology, and base-level falls created by river captures. Insights into drainage system and related landforms were provided by recent geomorphological studies on different sectors of the Stura Valley [22][23][24][25][26], and of the Italian and French sides of the Argentera Massif [27][28][29][30][31][32][33]. However, a robust basin-scale analysis of the existence and distribution of knickpoints, together with studies on their genesis, is still lacking.