Les médicaments de la toxoplasmose

Dardé, Marie Laure; Fougere, Édouard; Buxeraud, Jacques

doi:10.1016/j.actpha.2018.09.024

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“…In an investigation performed in 37 patients with the acute phase of toxoplasmosis, four presented low hemoglobin levels (10.8%), six leukopenia (16.2%), one thrombocytopenia (2.7%) and fourteen lymphocytosis (37.8%), which was the most frequent hematological alteration found (Neves et al 2009). According to these findings, we reported here the increase in lymphocytes counting as a noteworthy Pyrimethamine, a drug used for toxoplasmosis treatment, may produce a reduction in the neutrophils counting (Dardé et al 2018;Dunay et al 2018). This collateral effect could be the cause of changes in the white cells counting, however none of the study participants were under treatment with pyrimethamine in the moment of blood samples obtaining.…”

Section: Discussionsupporting

confidence: 59%

“…Pyrimethamine, a drug used for toxoplasmosis treatment, may produce a reduction in the neutrophils counting (Dardé et al 2018 ; Dunay et al 2018 ). This collateral effect could be the cause of changes in the white cells counting, however none of the study participants were under treatment with pyrimethamine in the moment of blood samples obtaining.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis

et al. 2020

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Toxoplasmosis is a zoonosis caused by Toxoplasma gondii, which can be acquired by oral contact and may cause severe health problems especially for pregnant (congenital toxoplasmosis) and immunocompromised patients. This study aimed to verify the diagnostic significance of hematological parameters and C-reactive protein (CRP) for toxoplasmosis acute detection. A case-control study was carried out between December 2017 and May 2018, in samples of convenience independent of age and sex. The case group was formed by 25 patients with positive anti-Toxoplasma gondii IgG/IgM antibody and the control group was formed by 21 patients with non-positive anti-Toxoplasma gondii IgG/IgM antibody. The results of the hematological parameters and CRP were analyzed in these patients. The patients with Toxoplasma gondii IgM antibody reagent showed higher lymphocytes counting and lower neutrophils counting than the control group. C-reactive protein levels were not different between the groups case and control. ROC curve analysis highlighted that the cutoff value of [ 32.00% for lymphocytes and \ 57.50% for neutrophils were able to produce specificity higher than 90% for IgM antibody detection. The Naïve Bayes classifier was considered suitable (AUC & 0.700) to separate both groups according to their white cell counting. Changes in lymphocytes and neutrophils may be useful parameters for toxoplasmosis identification and may be used as a tool in the complementary diagnosis of toxoplasmosis.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%