Les mycotoxines en alimentation humaine : un défi pour la recherche

Payros, Delphine; Garofalo, Marion; Pierron, Alix; Soler-Vasco, Laura; Al-Ayoubi, Carine; Maruo, Viviane Mayumi; Alassane-Kpémbi, Imourana; Pinton, Philippe; Oswald, Isabelle P.

doi:10.1016/j.cnd.2021.02.001

Cited by 15 publications

(1 citation statement)

References 107 publications

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“…Moreover, the emergence of new mycotoxins and the occurrence of masked mycotoxins pose additional challenges for food safety (Jestoi 2008;Galaverna et al 2009;Fraeyman et al 2017;Berthiller et al 2013;Gruber-Dorninger et al 2017;Ponce-García et al 2018;Ekwomadu et al 2020;Payros et al 2021).…”

Section: Global Overview Of the Mycotoxigenic Metabolome Of Fusarium ...mentioning

confidence: 99%

Time-variation study and OSMAC approach on fumonisin B1 and other mycotoxin production by Fusarium verticillioides.

Groppi,

Gadea,

Cristofoli

et al. 2023

Preprint

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Fusarium verticillioides is a plant pathogenic fungus that can cause disease in a variety of crops, including corn, sorghum, and cotton. It is commonly found in soil, but can also be found in infected seeds and plant debris. This fungus produces several mycotoxins, including fumonisins, which can be harmful to both humans and animals if ingested in high concentrations. It can also produce other toxins such as "emerging" mycotoxins like beauvericin, fusaproliferin and others. In this study, we aimed to expand our understanding of mycotoxin production by F. verticillioides according to the substrate. To do so, we investigated the ecophysiology of F. verticillioides under different culture conditions (media, humidity, temperature) over time through UHPLC-HRMS/MS analysis and a dereplicative approach. Our results showed a modification of the fungal growth but also a variation of the nature and the relative concentrations of the mycotoxins produced along the time according to the modifications of culture conditions. This experiment showed that corn meal agar (CMA) medium (MEA) was favorable for fumonisin A1 (FA1), fumonisin B1 (FB1) and fumonisin B2 (FB2) production while malt extract agar medium was favorable for fumonisin A2 (FA2) production. This study allowed us to understand the development conditions of this fungus and the occurrence of its mycotoxins depending on its substrate.

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Section: Global Overview Of the Mycotoxigenic Metabolome Of Fusarium ...mentioning

confidence: 99%

Time-variation study and OSMAC approach on fumonisin B1 and other mycotoxin production by Fusarium verticillioides.

Groppi,

Gadea,

Cristofoli

et al. 2023

Preprint

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Dietary Exposure to the Food Contaminant Deoxynivalenol Triggers Colonic Breakdown by Activating the Mitochondrial and the Death Receptor Pathways

Payros

Alassane-Kpémbi

Laffitte

et al. 2021

Molecular Nutrition Food Res

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Introduction: The food contamination by mycotoxins is of increasing public health concerns. Deoxynivalenol (DON), a mycotoxin contaminating cereals, has been associated with the exacerbation of inflammatory bowel diseases (IBD), thereby raising the question of its role in the development of IBD. Moreover, the effect of DON on the colon is poorly described. Methods and Results: Wistar rats exposed (1-4 weeks) to low doses of DON (2 or 9 mg kg −1 feed) show microscopic alterations of colonic tissue (dilated lymphatic vessels, luminal debris, and cubic and flattened enterocytes). Ingestion of DON also alters colonic functions by increasing paracellular permeability while reducing the expression of the tight junction proteins and increased apoptosis in colonic tissue. Pro-apoptotic factors Bax/Bak, cytochrome C, and caspase 9 are upregulated, whereas expression of anti-apoptotic protein Bcl2 tends to decrease for the mitochondrial pathway. An increased expression of FasR and caspase-8 is observed for the extrinsic pathway. An increase in the pro-inflammatory markers TNF𝜶, IL-17, and myeloperoxidase is also observed. Conclusion: These results indicate that the dietary exposure to low levels of DON in food targets the colon inducing a health-threatening breakdown of the colonic barrier, highlighting oral exposure to DON as a potential risk factor in triggering IBD.

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A precursor of Aflatoxin B1, Versicolorin A, impairs the mitochondrial function of human intestinal Caco-2 cells

Gauthier,

Puel,

Rocher

et al. 2024

Environment International

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Les mycotoxines en alimentation humaine : un défi pour la recherche

Cited by 15 publications

References 107 publications

Time-variation study and OSMAC approach on fumonisin B1 and other mycotoxin production by Fusarium verticillioides.

Time-variation study and OSMAC approach on fumonisin B1 and other mycotoxin production by Fusarium verticillioides.

Dietary Exposure to the Food Contaminant Deoxynivalenol Triggers Colonic Breakdown by Activating the Mitochondrial and the Death Receptor Pathways

A precursor of Aflatoxin B1, Versicolorin A, impairs the mitochondrial function of human intestinal Caco-2 cells

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