Les nanoparticules de silice mésoporeuse pour combattre le cancer

Abstract

Les nanoparticules de silice mé soporeuse pour combattre le cancer Ré sumé : Malgré les progrè s ré alisé s dans les domaines de la chimiothé rapie, radiothé rapie ou de la chirurgie, le dé veloppement de straté gies innovantes pour amé liorer la prise en charge des maladies cancé -reusesestindispensable.L'approche multidisciplinaire des nanotechnologies, associant physique, chimie, biologie, mathé matiques et ingé nierie, offrent des avancé es significatives dans les mé thodes de diagnostic, de traitement et de pré vention du cancer. Nous avons dé veloppé un systè me de nano-administration multi-niveaux (Multistage Delivery System) utilisant des particules de silicium mé soporeux qui permet de franchir les diffé rentes barriè res biologiques et de dé livrer in situ des agents thé rapeutiques aux cellules tumorales. En plus de cette nouvelle straté gie thé rapeutique, nous avons dé veloppé une plateforme de nanoproté omique permettant de dé tecter et identifier de nouveaux marqueurs pour le diagnostic pré coce et le suivi thé rapeutique. L'association de ces deux plateformes nanotechnologiques pré sente de fortes potentialité s pour le dé veloppement d'une vé ritable mé decine personnalisé e. Mots clé s : Silice -administration de mé dicament -traitements personnalisé s -proté oniqueAbstract: Despite the significant breakthroughs in tumor detection, surgery, chemotherapy, and radiotherapy, there remains a significant need for the development of innovative approaches to decrease cancer morbidity and mortality. Nanotechnology is a multidisciplinary approach associated with physics, biology, chemistry, mathematics, and engineering, offering unprecedented opportunities to improve the current medical and clinical practice. In this article, we present the development of multistage nanovector approach for a synergistic targeting and delivery of therapeutic agents, providing disruptive technology to overcome the biological barriers that impede efficient drug delivery. We further present an integrated multifunctional nanoproteomics platform combined with mass spectrometry for the screening and discovery of biomarkers for early diagnosis and therapy monitoring. These two nanotechnology platforms together will provide potential for development of an effective personalized medicine.

Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences

“…It is likely that this field of nanoproteomics applications will be able to partake in the current quest for personalized medicine, coupling both disease monitoring and targeted therapy . In this regard, Bouamrani et al (2009) proposed a multistage nanovector approach for both targeting and delivery of antineoplastic drugs. The system is built through combining multistage delivery systems: active components are carried by nanoporous silicon (Mahmoud et al, 2008;Tang and Hewlett, 2010) (Finnskog et al, 2006;Nam et al, 2003;Thaxton et al, 2009;Zheng et al, 2005) (Ansari et al, 2010;Guo et al, 2011;Kaushik et al, 2009;Yang et al, 2011) *HIV proteins, PSA, and ochratoxin-A protein with their detection levels are evaluated using different nano-platforms including: magnetic nanoparticles, metal oxides, composite nanosensor assay, Europium-based nanoparticles, carbon nanoparticles, gold nanoparticles, porous silica, and mass spectrometry-based approaches (NA is Not Available).…”