Les polymères synthétiques résorbables : caractéristiques et applications pour les prothèses artérielles

Correlation between Surface Properties of Polystyrene and Polylactide Materials and Fibroblast and Osteoblast Cell Line Behavior: A Critical Overview of the Literature

“…poly- d -lactide, poly- l -lactide, and poly- d , l -lactide), most of the research dedicated to bone repair has been focused on PLLA due to its superior mechanical behavior. Characterized by a well-established biocompatibility, the l -lactic acid released from its degradation can be eliminated through kidney filtration or recycled into the tricarboxylic acid cycle. − Macromolecular features of PLA, optimal isomer ratio, molecular weight, architecture, and crystallinity can be finely tuned to adjust its mechanical properties and its degradation rate. , With a melting temperature around 180 °C, PLA can be easily processed using traditional processing technologies, like extrusion, injection molding, compression molding, or blow molding. , PLA is notably adopted for screws and plates used in bone fixation, for surgical sutures in wound management, and also for drug delivery systems. ,− More recently, this polymer has been implemented as one of the most popular to produce scaffolds, notably using 3D printing …”

“…18,45−47 More recently, this polymer has been implemented as one of the most popular to produce scaffolds, notably using 3D printing. 49 In vitro, fibroblasts and osteoblasts can only survive if they can meet and interact with a surface on which they can adhere, spread, and proliferate. 50 Accordingly, the presence or absence of interaction with the surface induces signal transduction to the nucleus that respectively causes cell growth and differentiation or apoptosis and cell death.…”