Les polypes festonnés colorectaux : une entité revisitée

Bruno, Benedetto; Bézieau, Stéphane; Dufilhol, Cédric; Cauchin, Estelle; Heymann, Marie‐Françoise; Mosnier, Jean‐François

doi:10.1016/s0399-8320(07)89325-0

Cited by 9 publications

(4 citation statements)

References 79 publications

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“…20 Examples include basal squamous dysplasia of the esophagus, 21 crypt dysplasia in Barrett esophagus, 22 Pit dysplasia 23 and pyloric gland adenoma 24 in the stomach, and hyperplastic/serrated polyps of the colon. 25,26 Those lesions may maintain the capacity for cell differentiation and surface maturation, but at the meantime accumulate enough abnormalities for neoplastic transformation. Indeed, studies have shown that up to 20% of crypt DNA in patients with IBD had genetic alterations.…”

Section: Discussionmentioning

confidence: 99%

“…“Neoplasia without dysplasia” is a concept proposed recently from the observation that many neoplastic precursor lesions in the tubular gut lack conventional morphologic evidence of dysplasia yet serve as precursor lesions for neoplasia 20. Examples include basal squamous dysplasia of the esophagus,21 crypt dysplasia in Barrett esophagus,22 Pit dysplasia23 and pyloric gland adenoma24 in the stomach, and hyperplastic/serrated polyps of the colon 25,26. Those lesions may maintain the capacity for cell differentiation and surface maturation, but at the meantime accumulate enough abnormalities for neoplastic transformation.…”

Section: Discussionmentioning

confidence: 99%

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Small Intestinal Adenocarcinomas Arising in Enteritis Cystica Profunda With Metaplasia: A Report of 2 Cases

Zhang

Chen²,

Liao³

2021

Applied Immunohistochemistry &Amp; Molecular Morphology

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Enteritis cystica profunda (ECP) is an uncommon benign condition arising after mucosal damage. We describe 2 cases of small intestinal adenocarcinomas associated with ECP at the distal ileum, one in a background of active Crohn ileitis (case 1), the other 22 years after pelvic radiation therapy (case 2). Both patients presented with small bowel obstruction and received ileocectomy. Macroscopic examination identified an indurated/strictured area in the distal ileum. Histologically, both cases showed a low-grade tubuloglandular adenocarcinoma arising in a background of chronic ischemic stricture and ECP lined by flat cuboidal cells with mild cytologic atypia resembling pancreatobiliary-type epithelium. There was no conventional dysplasia in the surface or adjacent mucosa. Immunohistochemically, both ECP with metaplasia and invasive carcinomas were diffusely positive for CK7 and CK19, while focally positive for CDX2 or CK20. Both cases showed normal wildtype p53 expression. Case 2 was also mismatch repair protein proficient, with membranous β-catenin staining, and retained nuclear SMAD4 expression. In summary, the 2 cases uniquely exhibits "enteritis-metaplasia-carcinoma" sequence, which has not been reported before. This process appears to bypass conventional dysplasia, be slow and indolent, independent of p53, APC/β-catenin, and SMAD4/TGFβ signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Small Intestinal Adenocarcinomas Arising in Enteritis Cystica Profunda With Metaplasia: A Report of 2 Cases

Zhang

Chen²,

Liao³

2021

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…Elles sont caractérisées par la présence de multiples polypes hyperplasiques colorectaux, dont certains peuvent être atypiques du fait d'une grande taille et/ou d'une localisation colique proximale [4]. Elles sont associées à un risque accru de cancer colorectal, mais les données actuelles ne permettent pas de chiffrer précisément ce risque.…”

Section: Polyposes Hyperplasiquesunclassified

Les nouveautés dans les formes héréditaires des cancers colorectaux

2009

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Des progrès très significatifs ont été réalisés au cours des deux dernières décennies dans le domaine de l'oncogénétique digestive et notamment des formes hérédi-taires des cancers colorectaux. Ils sont abordés dans cet article et sont dominés par la description récente d'une nouvelle entité, la polypose adénomateuse associée à MYH, et par l'amélioration significative de nos connaissances relatives aux différents aspects du syndrome de Lynch : stratégie diagnostique, corrélations phénotype-génotype, mutations causales, prise en charge... Mots clés HNPCC · Polypose adénomateuse colique · MYHAbstract This review will be focused on the recent advances in the field of hereditary colorectal cancer syndromes. They are dominated by the identification of the new entity called « MYH-associated polyposis » and by significant advances in different aspects of Lynch syndrome: diagnosis, molecular basis, phenotypic-genotypic correlations, surveillance...

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“…Furthermore, some evidence suggests that colonoscopy may not be protective against right-sided colonic lesions [ 5 , 6 ]. Subtle flat lesions with a predilection for the proximal colon, particularly those with serrated histology, are becoming increasingly significant as potential factors for the lack of protection of colonoscopy proximally and stress the importance of adequate preparations [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Split-Dose Polyethylene Glycol Is Superior to Single Dose for Colonoscopy Preparation: Results of a Randomized Controlled Trial

Mohamed

Hilsden

Dubé

et al. 2016

Canadian Journal of Gastroenterology and Hepatology

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Background. The efficacy of colonoscopy in detecting abnormalities within the colon is highly dependent on the adequacy of the bowel preparation. The objective of this study was to compare the efficacy, safety, and tolerability of PEG lavage and split-dose PEG lavage with specific emphasis on the cleanliness of the right colon. Methods. The study was a prospective, randomized, two-arm, controlled trial of 237 patients. Patients between the age of 50 and 75 years were referred to an outpatient university screening clinic for colonoscopy. Patients were allocated to receive either a single 4 L PEG lavage or a split-dose PEG lavage. Results. Overall, the bowel preparation was superior in the split-dose group compared with the single-dose group (mean Ottawa score 3.50 ± 2.89 versus 5.96 ± 3.53; P < 0.05) and resulted in less overall fluid in the colon. This effect was observed across all segments of the colon assessed. Conclusions. The current study supports use of a split-dose PEG lavage over a single large volume lavage for superior bowel cleanliness, which may improve polyp detection. This trial is registered with ClinicalTrials.gov identifier NCT01610856.

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Les polypes festonnés colorectaux : une entité revisitée

Cited by 9 publications

References 79 publications

Small Intestinal Adenocarcinomas Arising in Enteritis Cystica Profunda With Metaplasia: A Report of 2 Cases

Small Intestinal Adenocarcinomas Arising in Enteritis Cystica Profunda With Metaplasia: A Report of 2 Cases

Les nouveautés dans les formes héréditaires des cancers colorectaux

Split-Dose Polyethylene Glycol Is Superior to Single Dose for Colonoscopy Preparation: Results of a Randomized Controlled Trial

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