Les pseudo-tumeurs inflammatoires du poumon

Bousnina, S.; Racil, H.; Marniche, K.; Hassine, E; L, El Fekih; F, El Mezni; Chabbou, A.

doi:10.1016/s0761-8417(04)72085-4

Cited by 10 publications

(7 citation statements)

References 4 publications

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“…This fusion leads to constitutive overexpression of the ALK, causing cell proliferation. [ 4 - 6 , 10 , 11 ] In our patient, the tumor is due to overexpression of the ALK, detected by immunohistochemistry, and is probably favored by recurrent respiratory infections.…”

Section: Discussionmentioning

confidence: 72%

“…Several hypotheses have been proposed such as an auto-immune mechanism or infectious origin. Indeed, 30% of cases are closely related to recurrent respiratory infections which are caused by several microorganisms such as Mycoplasma, Nocardia, Actinomycetes, Epstein-Barr and human herpes virus [ 2 , 3 , 5 , 6 , 10 ]. Other studies, however, suggest that it might be a true neoplasm due to the presence, at the myofibroblastic component, of a fusion gene involving the ALK gene, a tyrosine kinase oncogen located on chromosome 2p23, initially found to be arranged in anaplasic large cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…On gross examination, the tumor is well circumscribed but not encapsulated, firm and homogeneous, with sometimes some foci of necrosis. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

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A rare tumor of the lung: inflammatory myofibroblastic tumor

et al. 2012

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Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. It represents 0.7% of all lung tumors. We report the case of a three-year-old child who suffered from a chronic cough with recurrent respiratory infections. Chest X-ray and computed tomography revealed the presence of a left lower lobe lung mass. After pneumonectomy, histological examination combined with immunohistochemical study discovered an inflammatory myofibroblastic tumor.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8722069326962972.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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A rare tumor of the lung: inflammatory myofibroblastic tumor

et al. 2012

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“…The same clinical presentation may be seen in the plasma cell variant of Castelman disease, in which overproduction of interleukin 6 is thought to be the underlying cause of the systemic complaints 7 . Grossly, inflammatory myofibroblastic tumor was well circumscribed but not encapsulated, firm and homogenous with sometime areas of necrosis 8 . In our case, tumor was well circumscribed and showed grayish white cut surface.…”

Section: Discussionmentioning

confidence: 98%

Multiple intestinal and extraintestinal inflammatory yofibroblastic tumors-a rare presentation with review of literature

Sachin¹

2013

IOSR-JDMS

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“…This type of tumor contains differentiated myofibroblastic spindle cells, lymphocytes, and eosinophils [2]–[5]. It may occur in many organs including liver [6], lung [7], bladder [8], spleen [9], lymph nodes [10], kidney [11] and eye [12] in both children and adults, with possible systemic symptoms, occasional recurrence, and rare malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Epstein-Barr Virus DNA in Patients with Idiopathic Orbital Inflammatory Pseudotumor

Jin

Zhao

et al. 2013

PLoS ONE

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Inflammatory pseudotumors (IPT) are soft tissue tumors that include a diverse group of lesions characterized by inflammatory cell infiltration and variable fibrotic responses. Idiopathic orbital inflammatory pseudotumors (IOIP) are IPTs of unknown etiology that develop in the orbit. Due to the lack of well-defined pathogenic mechanisms, diagnosis and treatment of this disease remain a significant challenge. Epstein-Barr virus (EBV) infection, which causes significant lymphocyte infiltration, has been proposed to be involved in IOIP. This study tries to validate the relationship between EBV infection and the development of IOIP. Sixteen IOIP tissue samples were obtained from patients during surgical resection of the lesion. One Graves' ophthalmopathy tissue sample and 20 normal donors' plasma serves as controls. The plasma level of five EBV antibodies, including VCA-IgG, VCA-IgA, VCA-IgM, EA-IgG and EBNA1-IgG were examined. All plasma samples were EB-VCA-IgG positive and EB-VCA-IgM negative, suggesting that all people tested had been infected with EBV but not in the acute infection stage. EBV-DNA was detected in 15/16 (94%) of IOIP tissue samples despite different levels of lymphocyte infiltration and 5/16 plasma samples (31%) were detected EBV DNA positive which is higher than the normal controls (10%). Percent of positive plus suspected positive samples with one or more of the three important risk markers (VCA-IgA, EA-IgG, EBV-DNA) is 50% of the patients (8/16) which is much higher compare with the normal controls (20%). The results further reveal the relationship between IOIP and EBV infection.

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Les pseudo-tumeurs inflammatoires du poumon

Cited by 10 publications

References 4 publications

A rare tumor of the lung: inflammatory myofibroblastic tumor

A rare tumor of the lung: inflammatory myofibroblastic tumor

Multiple intestinal and extraintestinal inflammatory yofibroblastic tumors-a rare presentation with review of literature

Quantification of Epstein-Barr Virus DNA in Patients with Idiopathic Orbital Inflammatory Pseudotumor

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