To ensure the regular operation of the machine, there are so many decentralized monitoring sensors and control equipment used. However, complicated wiring for their power supply and signal transmission makes the assembly and maintenance of the ventilation system significantly more complex. [4][5][6] Fortunately, a promising solution is using energy harvesting devices to convert wind energy from the ventilation system into electricity. [7][8][9][10][11] Current approaches are using conventional wind energy harvesters based on wind turbines with complex mechanical structures. [12,13] However, these designs are complicated and costly, which limits them to be used conveniently in the ventilation system. [14][15][16] Triboelectric nanogenerator (TENG), based on triboelectrification and electrostatic induction, has merits of simple structure, light weight, low cost, and diverse material selection. [17][18][19][20][21] A more important feature is that the TENG is a viable technology to harvest wind energy and an applicable solution for self-powered sensing systems. [22][23][24][25][26][27][28][29] Under the same mechanical input, the TENG and the conventional electromagnetic generator (EMG)With the improvement of the airtightness of modern buildings, installing ventilation systems indoors is becoming increasingly important, which works for a long time continuously and needs to be monitored in real-time. However, the complex wiring of monitoring sensors makes assembly and maintenance more difficult. This work reports a hybridized triboelectric-electromagnetic nanogenerator (HNG) as a power supply of a self-powered wireless monitoring system for ventilation systems. The HNG integrates an air inlet cover, a stator with coils and interdigitated copper electrodes, a rotor with magnets, fluorinated ethylene propylene films, and optimized built-in wind blades. The HNG scavenges wind energy from a ventilation system and serves as a power supply for electric applications. Under the wind speed of 6.5 m s −1 in the ventilation system, the maximum stabilized voltage and maximum instantaneous current of the HNG are 177.5 V and 0.049 A, which can charge smartphones and light up a bulb. Furthermore, the HNG realizes the self-powered wireless transmission of temperature and humidity sensing nodes. This work demonstrates an effective wind energy harvester, providing an innovative strategy for monitoring the condition of the ventilation system and broadening the thoughts of prospective energy harvesting.