Les troubles neurologiques par carence en vitamine B12 : étude rétrospective de 26 cas

Maamar, M.; Tazi-Mezalek, Z.; Harmouche, H.; Ammouri, W.; Zahlane, M.; Adnaoui, M.; Aouni, M.; Mohattane, A.; Maaouni, A.

doi:10.1016/j.revmed.2006.01.012

Cited by 25 publications

(15 citation statements)

References 37 publications

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“…Neurological signs usually generate a clinical picture of combined sclerosis of the spinal cord. Disorders are usually predominant in the lower limbs 18–20. Large nerve fiber damage is responsible for ataxia, paresthesia, tendinous areflexia, and deep sensitivity disorders with Romberg’s signs.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Optimal management of pernicious anemia

Andrès¹,

Serraj²

2012

JBM

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Pernicious anemia (also known as Biermer’s disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%–50% of the causes of vitamin B12 deficiency in adults. Given its polymorphism and broad spectrum of clinical manifestations, pernicious anemia is a great pretender. Its diagnosis must therefore be evoked and considered in the presence of neurological and hematological manifestations of undetermined origin. Biologically, it is characterized by the presence of anti-intrinsic factor antibodies. Treatment is based on the administration of parenteral vitamin B12, although other routes of administration (eg, oral) are currently under study. In the present update, these various aspects are discussed with special emphasis on data of interest to the clinician.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Optimal management of pernicious anemia

Andrès¹,

Serraj²

2012

JBM

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“…Mean age at onset is in the fifth decade in North African studies [17,19]. It is more level in Healton study [7].…”

Section: Discussionmentioning

confidence: 99%

“…Neuromyelopathy by deficiency in Vitamin B12 is due to a deficit in an intrinsic factor or in an inability to deliver cobalamin from the food or from its carrying proteins [14][15][16]. Neuromyelopathy by deficiency in Vitamin B12 manifests by profound sensibility [17][18][19]. Involvement of large sensitive fibers increases the susceptibility to postural disorders.…”

Section: Introductionmentioning

confidence: 99%

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2016

PMRD

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“…[17] 4) Vitamin deficiency, secondary to malabsorption: folic acid and Vitamin B12. Neurological signs -especially combined sclerosis of the spinal cord -are associated with Vitamin B12 deficiency [18].…”

Section: )mentioning

confidence: 99%

Neurological Manifestations In Inflammatory Bowel Disease

Hnach,

Ajana,

BenbelbarhdadiI

et al. 2015

IJMS

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IntroductionThe purpose of this retrospective study was to report neurological manifestations noted in patients who were monitored for inflammatory bowel disease, in order to document the pathophysiological, clinical, progressive, and therapeutic characteristics of this entity. Material and methodsWe conducted a retrospective study on patients monitored -in the gastroenterology service in Ibn Sina Hospital in Rabat, Morocco-for inflammatory bowel disease from 1992 till 2013 and who developed neurological manifestations during its course. Patients with iatrogenic complications were excluded, as well as patients with cerebrovascular risk factors. Results There were 6 patients, 4 of whom have developed peripheral manifestations. Electromyography enabled the diagnosis to be made and the outcome was favorable with disappearance of clinical manifestations and normalization of the electromyography. The other 2 patients, monitored for Crohn's disease, developed ischemic stroke. Cerebral computed tomography angiography provided positive and topographic diagnosis. Two patients were admitted to specialized facilities. Conclusion Neurological manifestations in inflammatory bowel disease are rarely reported. Peripheral neuropathies and stroke remain the most common manifestations. The mechanisms of these manifestations are not clearly defined yet. Currently, we hypothesize the interaction of immune mediators.

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Les troubles neurologiques par carence en vitamine B12 : étude rétrospective de 26 cas

Cited by 25 publications

References 37 publications

Optimal management of pernicious anemia

Optimal management of pernicious anemia

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Neurological Manifestations In Inflammatory Bowel Disease

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