Leser–Trélat syndrome and squamous cell carcinoma of the bladder

Abstract

Sir, Paraneoplastic syndromes are contemporaneous with various malignant tumors. Leser–Trélat syndrome is a paraneoplastic syndrome associated with certain cancers, notably, breast, lung, kidney, hepato-digestive, melanoma, and lymphoma [1]. The pathogenesis of Leser–Trélat syndrome remains unknown. Exceptional observations associate Leser–Trélat with bladder carcinoma [2]. Herein, we report Leser–Trélat syndrome in a 75-year-old black patient with bladder carcinoma. The aim of this work is to report an unusual association. The patient was a 75-year-old male, a non-smoker, with no previous history, admitted to the urology department of the Brazzaville Hospital for bladder carcinoma. The tumor suspected on ultrasound was documented by anatomopathological examination. The incidental discovery of a rash of diffuse pigmented papules located preferentially on the trunk, consisting of lesions of variable size, measuring from 3 to 1 cm, with a soft or firm consistency and irregular surface (Fig. 1). These lesions were suggestive of seborrheic keratoses.