Lesión colestásica aguda por aceclofenaco

Titos-Arcos, JC; Hallal, Hacibe; Andrade, Raúl J.; Gálvez, José María Genis

doi:10.1016/j.gastrohep.2009.12.002

Cited by 1 publication

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References 6 publications

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“…However, studies have shown that aceclofenac is biotransformed into chemically reactive metabolites capable of binding covalently to certain protein targets in the hepatocytes of animals administrated the drug [4], [5]. In addition, in vitro studies also revealed that the metabolic activation in hepatocytes produced 4-hydroxyaceclofenac and 5hydroxyaceclofenac which was mediated by UDPglucuronosyltransferase and cytochrome P450 isozymes (CYP1, CYP2B, CYP2C, CYP2C11 and CYP3A) [6,7], [8].…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF ETHANOLIC EXTRACT OF MOMORDICA CHARANTIA ON ANTIOXIDANT AND INFLAMMATORY MARKERS IN MALE BALB/c MICE ADMINISTERED ACYCOR-PLUS

Ogungbe

2017

JRRS

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Introduction: Acycor-plus (ACY) is a single dose combined analgesic and anti-inflammatory drug. Prolonged usage and overdose often lead to gastro-intestinal ulcerations, inflammations and oxidative stress which increases the use of synthetic H2 antagonists such as cimetidine (CMT). Aims: This study was carried out to monitor the antioxidant and inflammatory effects of ethanolic extract of Momordica charantia (MC) in ACY-administered male Balb/c mice. Materials and Methods: Twenty-five mice weighing between 15-20g were equally divided into five groups and received normal saline (Control), 2.5mg/kg ACY alone (ACY), ACY combined with either 50mg/kg cimetidine (CMT) or 100mg/kg and 200mg/kg ethanolic extract of Momordica charantia (MC100 and MC200, respectively). The animals were sacrificed after three days by cervical dislocation and post-mitochondrial fractions of their livers, kidneys, small intestines and colons were used to assess the activities of antioxidant and inflammatory markers. Results: MC100 and MC200 significantly reduced antioxidant markers except catalase (CAT) when compared with ACY while they increased hepatic myeloperoxidase (MPO) and nitric oxide (NO) (p<0.05). Kidney and colonic MPO activities were significantly reduced by MC100. However, MC200 significantly increased renal CAT, superoxide dismutase (SOD) and SOD/(GPx+CAT) ratio with increased oxidative stress. Conclusion: It can be concluded that MC100 had comparable effect with CMT while MC200 might induce renal toxicity. However, further research is needed using other routes of administration.

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Section: Introductionmentioning

confidence: 99%

EFFECT OF ETHANOLIC EXTRACT OF MOMORDICA CHARANTIA ON ANTIOXIDANT AND INFLAMMATORY MARKERS IN MALE BALB/c MICE ADMINISTERED ACYCOR-PLUS

Ogungbe

2017

JRRS

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Lesión colestásica aguda por aceclofenaco

Cited by 1 publication

References 6 publications

EFFECT OF ETHANOLIC EXTRACT OF MOMORDICA CHARANTIA ON ANTIOXIDANT AND INFLAMMATORY MARKERS IN MALE BALB/c MICE ADMINISTERED ACYCOR-PLUS

EFFECT OF ETHANOLIC EXTRACT OF MOMORDICA CHARANTIA ON ANTIOXIDANT AND INFLAMMATORY MARKERS IN MALE BALB/c MICE ADMINISTERED ACYCOR-PLUS

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