Lesion network mapping for symptom localization: recent developments and future directions

Joutsa, Juho; Corp, Daniel T; Fox, Michael

doi:10.1097/wco.0000000000001085

Cited by 38 publications

(28 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Growing research has demonstrated that many disorders map to broad brain networks more than specific regions. 18 Recently, Joutsa et al 19 used lesion network mapping to investigate the functional connectivity of dispersed brain lesions that relieved ET symptoms. All lesion locations were functionally connected to the cerebellum and thalamus, thus revealing a common network mediating tremor relief defined by connectivity to key hubs in these regions.…”

Section: Introductionmentioning

confidence: 99%

Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

Younger,

Ellis,

Parsons

et al. 2023

Neurology

View full text Add to dashboard Cite

Background and Objectives:The cerebello-thalamo-cortical circuit plays a critical role in essential tremor (ET). However, abnormalities have been reported in multiple brain regions outside this circuit, leading to inconsistent characterization of ET pathophysiology. Here, we test whether these mixed findings in ET localize to a common functional network and if this network has therapeutic relevance.Methods:We conducted a systematic literature search to identify studies reporting structural or metabolic brain abnormalities in ET. We then employed ‘coordinate network mapping’, which leverages a normative connectome (n= 1000) of resting-state fMRI data to identify regions commonly connected to findings across all studies. To assess whether these regions may be relevant for treatment of ET, we compared our network to a therapeutic network derived from lesions that relieved ET. Finally, we investigated whether the functional connectivity of this ET symptom network is abnormal in an independent cohort of ET patients as compared to healthy controls.Results:Structural and metabolic brain abnormalities in ET were located in heterogeneous regions throughout the brain, but connected to a common functional network of brain regions, including the cerebellum, thalamus, motor cortex, precuneus, inferior parietal lobe and insula. The cerebellum was identified as the hub of this network as it was the only brain region that was both functionally connected to over 90% of studies’ findings, and significantly different in connectivity compared to a control dataset of other movement disorders. This network was strikingly similar to the therapeutic network derived from lesions improving ET, with key regions aligning in the thalamus and cerebellum. Further, functional connectivity between the cerebellar network hub and the sensorimotor cortices was significantly reduced in ET patients compared to healthy controls, and connectivity within this network was correlated with tremor severity and cognitive functioning.Discussion:The cerebellum is the central hub of a network commonly connected to structural and metabolic abnormalities in ET. This network may have therapeutic utility in refining and informing new targets for neuromodulation of ET.

show abstract

Section: Introductionmentioning

confidence: 99%

Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

Younger,

Ellis,

Parsons

et al. 2023

Neurology

View full text Add to dashboard Cite

show abstract

“…By this simple association or correspondence, LNM has been capable of explaining the presence or absence of a similar symptom within a clinical cohort, depending on whether or not the patients' lesions are connected to a common network. Importantly, a recent review has shown that while LSM was not sufficient to explain motor, non-motor, sensory and behavioral changes after brain damage, LNM successfully explained a total of 40 different changes 52 , relating symptoms to lesions connected to a common network, and where more often than not, the location of the lesion alone (the gold standard in clinical practice) was not able to explain these symptoms.…”

Section: Discussionmentioning

confidence: 99%

Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients

Jiménez-Marín

Bruyn

Gooijers

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Beyond the characteristics of a brain lesion, such as its etiology, size or location, lesion network mapping (LNM) has shown that similar symptoms after a lesion reflects similar dis-connectivity patterns, thereby linking symptoms to brain networks. Here, we extend LNM by using a multimodal strategy, combining functional and structural networks from 1000 healthy participants in the Human Connectome Project. We apply multimodal LNM to a cohort of 54 stroke patients with the aim of predicting sensorimotor behavior, as assessed through a combination of motor and sensory tests. Results are two-fold. First, multimodal LNM reveals that the functional modality contributes more than the structural one in the prediction of sensorimotor behavior. Second, when looking at each modality individually, the performance of the structural networks strongly depended on whether sensorimotor performance was corrected for lesion size, thereby eliminating the effect that larger lesions generally produce more severe sensorimotor impairment. In contrast, functional networks provided similar performance regardless of whether or not the effect of lesion size was removed. Overall, these results support the extension of LNM to its multimodal form, highlighting the synergistic and additive nature of different types of network modalities, and their corresponding influence on behavioral performance after brain injury.

show abstract

“…Further adjustment for potential confounders was not possible due to the small number of subjects with overlap. Future studies in larger datasets and the use of alternative mapping methods such as lesion network mapping that allows for localization of symptoms to brain circuits rather than individual brain lesions could help better understand the causality 51 …”

Section: Discussionmentioning

confidence: 99%

Stroke‐Related Visceral Alterations: A Voxel‐Based Neuroanatomic Localization Study

Arsava,

Chang,

Tawakol

et al. 2023

Annals of Neurology

View full text Add to dashboard Cite

ObjectiveFunctional and morphologic changes in extracranial organs can occur after acute brain injury. The neuroanatomic correlates of such changes are not fully known. Herein, we tested the hypothesis that brain infarcts are associated with cardiac and systemic abnormalities (CSAs) in a regionally specific manner.MethodsWe generated voxelwise p value maps of brain infarcts for poststroke plasma cardiac troponin T (cTnT) elevation, QTc prolongation, in‐hospital infection, and acute stress hyperglycemia (ASH) in 1,208 acute ischemic stroke patients prospectively recruited into the Heart–Brain Interactions Study. We examined the relationship between infarct location and CSAs using a permutation‐based approach and identified clusters of contiguous voxels associated with p < 0.05.ResultscTnT elevation not attributable to a known cardiac reason was detected in 5.5%, QTc prolongation in the absence of a known provoker in 21.2%, ASH in 33.9%, and poststroke infection in 13.6%. We identified significant, spatially segregated voxel clusters for each CSA. The clusters for troponin elevation and QTc prolongation mapped to the right hemisphere. There were 3 clusters for ASH, the largest of which was in the left hemisphere. We found 2 clusters for poststroke infection, one associated with pneumonia in the left and one with urinary tract infection in the right hemisphere. The relationship between infarct location and CSAs persisted after adjusting for infarct volume.InterpretationOur results show that there are discrete regions of brain infarcts associated with CSAs. This information could be used to bootstrap toward new markers for better differentiation between neurogenic and non‐neurogenic mechanisms of poststroke CSAs. ANN NEUROL 2023

show abstract

Lesion network mapping for symptom localization: recent developments and future directions

Cited by 38 publications

References 38 publications

Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients

Stroke‐Related Visceral Alterations: A Voxel‐Based Neuroanatomic Localization Study

Contact Info

Product

Resources

About