Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to d-amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens

Simon, H.; Taghzouti, Khalid; Gozlan, H.; Studler, Jeanne-Marie; Louilot, Alain; Hervé, Denis; Głowiński, J.; Tassin, Jean‐Pol; Moal, Michel Le

doi:10.1016/0006-8993(88)91136-5

Cited by 121 publications

(41 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rats that performed more lever-press sign-tracking CRs showed more novelty stress-induced corticosterone release, higher DA levels in NAC, lower DOPAC/DA turnover ratios in caudate putamen, lower 5-HIAA/5-HT turnover in the VTA, but no evidence of elevated dopamine activity in PFC. Similarly, rats that more readily self-administer amphetamine showed more novelty stress-induced corticosterone release (Piazza et al, 1989;Rouge-Pont et al, 1993;Piazza and Le Moal, 1996;Lucas et al, 1998), higher indices of DA functioning in NAC (Piazza et al, 1989;Rouge-Pont et al, 1993;Piazza and Le Moal, 1996;Lucas et al, 1998), but not in PFC (Simon et al, 1988;Piazza et al, 1991) and lower indices of 5-HT functioning in VTA (Piazza et al, 1991; see also Kelland et al, 1990). These results add to the growing body of evidence suggesting that sign-tracking and drug abuse may be related phenomena (Tomie, 1995a(Tomie, , 1996Tomie et al, 2000;Everitt et al, 2001;Uslaner et al, 2006;Flagel et al, 2007a, b).…”

Section: Vulnerability Markerssupporting

confidence: 56%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

153

134

View full text Add to dashboard Cite

Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian signtracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Signtracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered.

show abstract

Section: Vulnerability Markerssupporting

confidence: 56%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

153

134

View full text Add to dashboard Cite

show abstract

“…As expected, MUS infusion doubled the amount of tastant consumed, eliminating CTA to the citric acid (MUS rats consumed as much as unpaired controls, consumption of which is shown by the horizontal dashed line). amygdalar dopamine projections (Simon et al 1988;Lipska et al 1992;Joseph et al 2000). Furthermore, hippocampectomy affects this system in ways that evolve, recover, and even change sign over time (Lanier et al 1975;Hannigan Jr. et al 1984;Lipska et al 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Such lesions have complex effects, downregulating some systems and upregulating others; during the 1-2 wk of recovery that must pass before rats with permanent lesions are healthy enough to participate in experiments, these changes evolve in a way that may extend, mask, or compensate for acute loss of hippocampal activity (e.g., Hannigan Jr. et al 1984;Simon et al 1988;Lipska et al 1992). Because particular parts of the systems that interact with the hippocampus are deeply involved in sensory aspects of CTA (Reilly and Bornovalova 2005), it is possible that temporary hippocampal inactivations might have an effect, even a facilitory one, on CTA, despite the lack of such effects observed on the majority of tasks.…”

mentioning

confidence: 99%

Hippocampal inactivation enhances taste learning

Stone¹,

Grimes²,

Katz³

2005

Learn. Mem.

View full text Add to dashboard Cite

Learning tasks are typically thought to be either hippocampal-dependent (impaired by hippocampal lesions) or hippocampal-independent (indifferent to hippocampal lesions). Here, we show that conditioned taste aversion (CTA) learning fits into neither of these categories. Rats were trained to avoid two taste stimuli, one novel and one familiar. Muscimol infused through surgically implanted intracranial cannulae temporarily inactivated the dorsal hippocampus during familiarization, subsequent CTA training, or both. As shown previously, hippocampal inactivation during familiarization enhanced the effect of that familiarization on learning (i.e., hippocampal inactivation enhanced latent inhibition of CTA); more novel and surprising, however, was the finding that hippocampal inactivation during training sessions strongly enhanced CTA learning itself. These phenomena were not caused by specific aspects of our infusion technique-muscimol infusions into the hippocampus during familiarization sessions did not cause CTAs, muscimol infusions into gustatory cortex caused the expected attenuation of CTA, and hippocampal inactivation caused the expected attenuation of spatial learning. Thus, we suggest that hippocampal memory processes interfere with the specific learning mechanisms underlying CTA, and more generally that multiple memory systems do not operate independently.

show abstract

“…Since mesoprefrontal DA-systems modulate the spontaneous activity of postsynaptic prefrontal pyramidal cells (Mora et al, 1976;Ferron et al, 1984), any change in ontogenesis of these prefrontal target cells, including further afferent systems, might also affect the maturation of prefrontal control over various subcortical systems (cf. Pycock et al, 1980;Simon et al, 1988;Taghzouti et al, 1988;Louilot et al, 1989;Thierry et al, 1990).…”

Section: Discussionmentioning

confidence: 98%

Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Dawirs

Teuchert-Noodt

Czaniera

1996

J. Neural Transmission

View full text Add to dashboard Cite

A single dose of methamphetamine (50 mg/kg; i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days, and adult prefrontal cortex (PFC)-related behaviours were analysed and compared with saline-treated controls at the age of postnatal day 90. For that purpose, animals were tested for open-field activities and y-maze delayed alternation. This solitary and non-invasive drug challenge, which has recently been found to initiate serious restraint in maturation of the mesoprefrontal dopamine (DA)-system (Dawirs et al., 1994), induces a significant delayed alternation impairment as well as significant increases in open-field motor activity and emotionality. Since an undisturbed development of the prefrontal DA-innervation seems to be a precondition for the maturation of normal PFC-related behaviours, a single early methamphetamine impact may be a suitable animal model for further investigation of structural and functional aspects of non-invasively induced behavioural deficits in rodents. The present results are discussed with regard to the assumption that hypofunctional mesoprefrontal DA-systems might be basic to schizophrenic behaviours in man.

show abstract

Lesion of dopaminergic terminals in the amygdala produces enhanced locomotor response to d-amphetamine and opposite changes in dopaminergic activity in prefrontal cortex and nucleus accumbens

Cited by 121 publications

References 30 publications

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Hippocampal inactivation enhances taste learning

Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus)

Contact Info

Product

Resources

About