While optical frequency domain imaging (OFDI) can delineate calcium modi cation and fracture, the capability of high-de nition intravascular ultrasound (HD-IVUS) for detecting these remains unclear. This study evaluated the diagnostic accuracy of HD-IVUS for assessing calcium modi cation and fracture as compared to OFDI.
MethodsHD-IVUS and OFDI were used during orbital or rotational atherectomy procedures conducted for 21 heavily calci ed coronary lesions in 19 patients. With OFDI assessment used as the gold standard, diagnostic accuracies of HD-IVUS for calcium modi cation and fracture were compared every 1 mm to the matched pre-stenting images (n=1,129). Calcium modi cation, as assessed by OFDI, was de ned as polished and concave-shaped calcium. For HD-IVUS, calcium modi cation was de ned as the presence of reverberation with concave-shaped calcium. In both assessments, the de nition of calcium fracture was de ned as a slit or complete break in the calcium plate.
ResultsCalci ed plaque was found in 86.4% of analyzed OFDI images. Calcium modi cation and fracture were detected in 20.6% and 11.0% of detected calci ed plaques. Sensitivity, speci city, positive and negative predictive values of HD-IVUS detection for calcium modi cation and fracture were 54.4%, 97.8%, 86.7%, 89.1% and 86.0%, 94.5%, 58.2%, 96.8%, respectively. Discordance cases between both assessments demonstrated that heterogeneous calcium visualized by OFDI, separated calcium and guide wire artifact can be misdiagnosed.
ConclusionDiagnostic accuracies of HD-IVUS for assessing calcium modi cation and fracture were modest as compared to OFDI. These results suggest that OFDI guidance is more feasible during treatment of heavily calci ed coronary lesions versus HD-IVUS guidance.