Lesions of the Corpus Callosum: MR Imaging and Differential Considerations in Adults and Children

Bourekas, Eric C.; Varakis, Kaliope; Bruns, Douglas; Christoforidis, Gregory A.; Baujan, Melissa; Slone, H. Wayne; Kehagias, Dimitrios

doi:10.2214/ajr.179.1.1790251

Cited by 108 publications

(76 citation statements)

References 7 publications

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“…Lymphomas can be multi-centric; with less enhancement and edema compared to GBM [1]. They also spread along white matter tracts and can cross the midline via the corpus callosum.…”

Section: Check For Updatesmentioning

confidence: 99%

“…It is a heterogonous necrotic mass with surrounding edema and ring enhancement as seen in Figure 2. They typical extend along white matter tracts including the corpus callosum [1]. Meningioma is a common primary brain tumor, but rare in the corpus callosum.…”

Section: Differentialmentioning

confidence: 99%

“…Primary Central Nervous System Lymphoma (PCNSL) is a rare aggressive neoplasm found within the brain, commonly in the corpus callosum, deep gray matter structures or the periventricular region [1]. PCNSL is a non-Hodgkin type tumor predominantly composed of diffuse large B-cells and accounts for less than 2% of malignant brain tumors [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…PCNSL is a non-Hodgkin type tumor predominantly composed of diffuse large B-cells and accounts for less than 2% of malignant brain tumors [1,2]. According to WHO 2008 classification, PCNSL is considered a mature B-cell neoplasm [3].…”

Section: Introductionmentioning

confidence: 99%

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2018

Neurosurg Cases Rev

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We report a case of a 71-year-old Caucasian female who presented with two to three weeks of horizontal diplopia and coordination difficulty in the right upper extremity. She also reported weight loss and a low grade fever. Patient had a medical history of hypertension, hyperlipidemia, hypothyroidism, and anxiety and a family history of hypertension only. Patient reported she was a former smoker of 4-5 cigarettes a day for 2-3 years in her 20s, drinks alcohol socially, and has never participated in illicit drug use.Her physical finding of note included right homonymous upper quadrantanopia, binocular diplopia evident upon looking to the left, normal other cranial nerves, right upper extremity strength of graded 5/5-proximally and 4+/5 distally, right upper extremity past pointing and subtle ataxia on the right, including finger to nose and the heel to shin test, as well as gait ataxia.MRI of the brain was performed with and without contrast and showed multiple hyper-intense lesions involving the basal ganglion, thalamus, midbrain, pons, temporal lobe, occipital lobe, and enhancing corpus callosal lesions. There was no evidence of edema, necrosis, or ring enhancement, as shown in Figure 1. Lesions were found to cross the midline via the corpus callosum.The differential diagnosis included neoplasms, demyelinating disorders and autoimmune and inflammatory conditions, infections, vascular causes, and trauma, which are discussed below along with representative MRI images. AbstractPrimary Central Nervous System Lymphoma (PCNSL) is a rare non-Hodgkin type neoplasm, which crosses the midline. We report an unusual case of a 71-year-old Caucasian female who was shown to have PCNSL by a tissue biopsy after the brain Magnetic Resonance Imaging (MRI) showed Central Nervous System (CNS) lesions crossing the corpus callosum. We propose that PCNSL should be considered in the differential diagnosis of midline crossing lesions. Awareness of this is imperative for treatment decisions for such patients.

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“…Lymphomas can be multi-centric; with less enhancement and edema compared to GBM [1]. They also spread along white matter tracts and can cross the midline via the corpus callosum.…”

Section: Check For Updatesmentioning

confidence: 99%

Section: Differentialmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2018

Neurosurg Cases Rev

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“…Therefore, injury of the CC can result in various and severe manifestations depending on the location of the lesion, such as callosal disconnection syndrome (CDS), which is characterized by impairment of interhemispheric transfer of information due to interruption of transcallosal fibers (TCF) [3][4][5][6]. In addition, the CC has been a target structure for surgery to control seizure and for tumor resection [7].…”

Section: Introductionmentioning

confidence: 99%

Anatomical location of transcallosal sensorimotor fibers in the human brain: Diffusion tensor tractography study

Seo

Jang

2013

Translational Neuroscience

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Many diffusion tensor tractography (DTT) studies have reported on the topography of transcallosal fibers (TCF). However, little detailed anatomical information on TCF that can be easily applied for clinical purposes is known. Using probabilistic DTT, we attempted to determine the anatomical location of the TCF for motor and sensory function in the human brain. A total of 51 healthy subjects were recruited for this study. Diffusion tensor images (DTIs) were obtained at 1.5 T, and four TCF for the premotor cortex (PMC), the primary motor cortex (M1) for hand and leg, and the primary somatosensory cortex (S1) were obtained using FMRIB software. Locations of the TCF were defined as the highest probabilistic location on the midsagittal slice of the corpus callosum. We measured distances between the most anterior and posterior points of the corpus callosum. The relative mean distances of the highest probabilistic location for the precentral knob PMC (Brodmann area 6 anterior to the precentral knob), hand M1, leg M1, and precentral knob S1 (postcentral gyrus posterior to the precentral knob) TCF were 48.99%, 59.78%, 67.93%, and 73,48% from the most anterior point of the CC, respectively. According to our findings, the precentral knob PMC, hand M1, leg M1, and precentral knob S1 TCF were located at the anterior body, posterior body, posterior body, and isthmus according to Witelson's classification, respectively.

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