Lesions of the nervous system associated with relapsing polychondritis

Chernyak, V. I.; Savel'ev, A I; Pogromov, A P

doi:10.18821/0023-2149-2016-94-2-108-113

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Patients often have a high level of neuroticism, anxiety, depressive states, and "somatovegetative disorders." Anxiety is observed in approximately 50% of patients with functional GIT diseases [82][83][84][85][86][87][88][89][90][91]. It is known that anxiety is induced by a stress response mediated primarily through the release of corticotropin-releasing hormone from the hypothalamus.…”

Section: Evolution Of Ideas About Functional Diseases Of the Gastroin...mentioning

confidence: 99%

“…ψυχή means soul and σ μα means body. Psychosomatic medicine is a branch of medical psychology that studies the influence of psychological factors on the occurrence, course, and outcome of somatic (body) diseases [86][87][88][89][90][91]. The Rome Process and the Rome Criteria are an international effort to collect scientific data that can help in the diagnosis and treatment of functional psychosomatic gastrointestinal disorders [82][83][84].…”

Section: Problems and Prospectsmentioning

confidence: 99%

“…According to the new definition proposed by the expert council of the Rome Foundation IV Revision (2016), functional GIT diseases are disorders of the interaction of the brain and GIT. Within the framework of the new model of the formation of functional diseases of the GIT, the dysfunction of the "brain-intestine" axis at the sensory, motor, and neuroendocrine levels occupies a central place [82][83][84][85][86][87][88][89][90][91].…”

Section: Problems and Prospectsmentioning

confidence: 99%

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Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Реутов

Sorokina

2022

BIOPHYSICS

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The brain and gastrointestinal tract are the most important organs responsible for detecting, transmitting, integrating, and responding to signals coming from the internal and external environment. A bidirectional system of neurohumoral communication (the "intestine-brain" axis) combines the activity of the intestine and brain (or brain and intestine) of a person. It affects human development and behavior. This paper analyzes the literature data on the existence of a relationship between the central and enteral nervous systems. Based on data on the number of neurons in the enteral nervous system (approximately 250 million nerve cells), the concept of a "second brain" in the intestine has been proposed in foreign literature, which, by its influence on the brain, can have a more powerful influence than the spinal cord (approximately 10 million neurons) with its autonomic nervous system. However, it turned out that Russian scientists, academicians of the Academy of Sciences of the Soviet Union I.P. Pavlov, K.M. Bykov, and A.M. Ugolev, analyzed cortical-visceral relationships in the 20th century and wrote about the existence of a connection between the central and enteral nervous systems. One of the urgent problems of modern physiology, pathophysiology, biophysics, biochemistry, and medicine is to clarify the causal relationship between the central and enteral nervous systems, as well as between neurological, mental, and gastrointestinal diseases in order to combine the efforts of specialists of various medical and biological profiles to solve urgent medical problems.

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Section: Evolution Of Ideas About Functional Diseases Of the Gastroin...mentioning

confidence: 99%

Section: Problems and Prospectsmentioning

confidence: 99%

Section: Problems and Prospectsmentioning

confidence: 99%

See 1 more Smart Citation

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Реутов

Sorokina

2022

BIOPHYSICS

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A clinical case of recurrent polychondritis in a middle-aged woman

Kulagin

2024

Clinical Medicine and Pharmacology

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A case of recurrent polychondritis with damage to cartilage tissue (perichondritis) of the auricles, the back of the nose, and episcleritis in a 38-year-old woman is presented. The case is notable for the presence of characteristic clinical symptoms of a rare pathology, a long undulating course of the disease with periods of exacerbation and remission, as well as multiple changes in treatment regimens and the occurrence of an iatrogenic complication of drug therapy - Itsenko-Cushing syndrome.

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Relapsing Polychondritis: Problems and Solutions

Zhuravleva,

Dibrov,

Ivanova

et al. 2024

Acta med. Eurasica

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The purpose of this study is to evaluate the clinical course and effectiveness of pharmacological therapy in a patient with recurrent polychondritis. Material and methods. Retrospective and prospective analyses of the diagnosis, course and treatment of recurrent polychondritis in the patient were performed. The patient was diagnosed based on the McAdam classification criteria. The patient was assigned laboratory tests: general, biochemical and immunological blood analyses; instrumental methods: X-ray and ultrasound examinations of the vessels, spirometry. The results of the study. The patient was first diagnosed with recurrent polychondritis at the age of 58. The patient complained of pain, swelling and hyperemia of the auricles, a change in the shape of the nose; attacks of suffocation, which were stopped by inhalations of salbutamol, hoarseness of voice; prolonged subfebrility (37.5–38°C), arthralgia. In September 2022, he was examined by an otolaryngologist, then sent to a rheumatologist to determine therapeutic and diagnostic tactics. According to the results of laboratory data: erythrocyte sedimentation rate – 48 mm/hour, C-reactive protein – 30.1 mg/l, rheumatoid factor – 10 units/l, antibodies to cyclic citrulline peptide- 7.0 units, the result of immunoblot is negative; antibodies to myeloperoxidase – 4.15 RU/ml, antibodies to proteinase – 32.2 RU/ml. During spirometry, there was a violation of the function of external respiration of an obstructive type. Ultrasound of the joints: signs of synovitis of the proximal interphalangeal joints of both hands. Based on the McAdam classification criteria, a clinical diagnosis was made: recurrent polychondritis with systemic manifestations: chondritis of the auricles and nasal congestion, seronegative arthritis, bronchoobstructive syndrome, constitutional symptom (fever). The patient was prescribed therapy: prednisone 20 mg/day, methotrexate 25 mg/week. Clinical and laboratory remission was achieved, but subsequently relapses of the disease and the appearance of a herpes infection were observed (antiviral therapy was prescribed). In July 2023, he was sent for examination and treatment at the Nasonova Research Institute of Rheumatology. The patient was submitted to the commission on therapy with genetically engineered biological drugs. Taking into account the often recurrent herpetic infection, the appointment of genetically engineered biological drugs was postponed. It is recommended to continue taking prednisolone at a dose of 20 mg/day, antiviral therapy (valciclovir). Dapsone 100 mg per day was added to the treatment, but his patient independently canceled the drug due to the appearance of severe nausea and insomnia. Subsequently, a rheumatologist with an immunosuppressive purpose prescribed azathiroprine 150 mg/day, continued taking prednisone 20 mg/day, however, exacerbations of the disease were registered. The lack of effect of the therapy was the basis for the patient's re-hospitalization at the V.A. Nasonova Research Institute of Rheumatology. Conclusions. Recurrent polychondritis is a rapidly progressive disease, and in the absence of timely diagnosis and treatment, it has a risk of developing life-threatening conditions.

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Lesions of the nervous system associated with relapsing polychondritis

Cited by 3 publications

References 6 publications

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

A clinical case of recurrent polychondritis in a middle-aged woman

Relapsing Polychondritis: Problems and Solutions

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