Less fibrosis in elderly subjects supplemented with selenium and coenzyme <scp>Q</scp>10—A mechanism behind reduced cardiovascular mortality?

Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Svensson, Erland; Johansson, Peter; Larsson, Anders

doi:10.1002/biof.1404

Cited by 23 publications

(16 citation statements)

References 52 publications

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“…In a previous publication our group presented data indicating less fibrosis in seven out of eight evaluated biomarkers for fibrosis in the population receiving SeQ 10 compared with those on placebo. This could indicate a possible anti-ageing effect on the cardiovascular system, as the ageing process is highly associated with increased fibrosis of the cardiovascular system [59]. Increased expression and synthesis of selenoprotein P following selenium supplementation requires SAM-dependent protein methylation [57].…”

Section: Discussionmentioning

confidence: 99%

Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population

et al. 2019

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Selenium and coenzyme Q10 (SeQ10) are important for normal cellular function. Low selenium intake leads to increased cardiovascular mortality. Intervention with these substances with healthy elderly persons over a period of four years in a double-blind, randomised placebo-controlled prospective study showed reduced cardiovascular mortality, increased cardiac function, and a lower level of NT-proBNP. Therefore, we wanted to evaluate changes in biochemical pathways as a result of the intervention with SeQ10 using metabolic profiling. From a population of 443 healthy elderly individuals that were given 200 µg selenium and 200 mg coenzyme Q10, or placebo daily for four years, we selected nine males on active intervention and nine males on placebo for metabolic profiling in the main study. To confirm the results, two validation studies (study 1 n = 60 males, study 2 n = 37 males) were conducted. Principal component analyses were used on clinical and demographic data to select representative sets of samples for analysis and to divide the samples into batches for analysis. Gas chromatography time-of-flight mass spectrometry-based metabolomics was applied. The metabolite data were evaluated using univariate and multivariate approaches, mainly T-tests and orthogonal projections to latent structures (OPLS) analyses. Out of 95 identified metabolites, 19 were significantly decreased due to the intervention after 18 months of intervention. Significant changes could be seen in the pentose phosphate, the mevalonate, the beta-oxidation and the xanthine oxidase pathways. The intervention also resulted in changes in the urea cycle, and increases in the levels of the precursors to neurotransmitters of the brain. This adds information to previous published results reporting decreased oxidative stress and inflammation. This is the first-time metabolic profiling has been applied to elucidate the mechanisms behind an intervention with SeQ10. The study is small and should be regarded as hypothesis-generating; however, the results are interesting and, therefore, further research in the area is needed. This study was registered at Clinicaltrials.gov, with the identifier NCT01443780.

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Section: Discussionmentioning

confidence: 99%

Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population

et al. 2019

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“…Было также замечено, что через 48 месяцев после начала исследования уровень марке-ра NT-proBNP в группе, принимающей добавки, был значительно ниже, чем в группе плацебо (214 нг / л против 302 нг / л, р=0,014), что указывает на меньшие риски развития сердечной недостаточности. Изучение результатов эхокардиографии сердца выявило значительное улучшение сердечных функций у людей, принимавших комбинацию веществ, при сравнении с результатами, полученными от группы плацебо [56].…”

Section: эффекты селена в составе различных структурunclassified

The role of selenium in cardiology

2021

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Selenium is an important micronutrient that is essential for the functioning of the human body. Being a component of the active center of several antioxidant enzymes selenium prevents cell injury by free radicals. Decline in selenium-containing enzymes results in progression of oxidative stress and chronic inflammation, which are considered as possible causes for the development of many cardiovascular diseases. This review focuses on mechanisms for prevention of myocardial and vascular injury through the adequate selenium supply to the body. The importance of monitoring and correction of the selenium status in appropriate patients is underlined.

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“…Among trials conducted in patients with CVD, CoQ10 was tested alone or with antioxidant supplements [ 45 , 46 , 47 , 48 , 49 ] and beneficial effects included decreased fibrosis, morbidity, and mortality, as well as decreased levels of pro-inflammatory cytokines, with improved left ventricular function and quality of life. A clinical trial conducted in CVD patients by McMackin et al [ 18 ], testing a combination of ALA and acetyl-CARN, reported a significant improvement of blood pressure and vascular tone.…”

Section: Mitochondrial Nutrient-based Clinical Trials In Aging-relmentioning

confidence: 99%

“…Two other clinical trials [ 50 , 51 ] were conducted on acyl-CARN in CVD patients, which also reported positive effects on CVD endpoints, as well as OS parameters such as decreased concentrations of malondialdehyde and 4-hydroxynonenal. Altogether, one may recognize that CVD patients may benefit from adjuvant treatments with CoQ10, ALA, and acyl-CARN [ 18 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Mitochondrial Nutrient-based Clinical Trials In Aging-relmentioning

confidence: 99%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential–and distinct—roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10—A mechanism behind reduced cardiovascular mortality?

Cited by 23 publications

References 52 publications

Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population

Significant Changes in Metabolic Profiles after Intervention with Selenium and Coenzyme Q10 in an Elderly Population

The role of selenium in cardiology

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

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