Less HLA-G Expression in Plasmodium falciparum-Infected Third Trimester Placentas is Associated with More Natural Killer Cells

Sartelet, Hervé; Schleiermacher, Dietlind; Hesran, Jean-Yves Le; Graesslin, O.; Gaillard, David; Fe, McKenzie; Lechki, C.; Gaye, Alioune; Bouteiller, P. Le; Birembaut, Philippe

doi:10.1016/j.placenta.2004.08.006

Cited by 24 publications

(21 citation statements)

References 34 publications

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“…This hypothesis requires further investigations. Contrary to the IFN-␥/NK results discussed here, Sartelet et al (26) report significantly higher levels of NK cells in infected placentas than in noninfected placentas and they associate the elevated NK-cell numbers to poor birth outcomes. Sartelet's study investigated placental tissue by immunohistochemistry in a focused group of placentas obtained from women with poor birth outcomes.…”

Section: Investigations Of Cd4contrasting

confidence: 99%

Elevated Gamma Interferon-Producing NK Cells, CD45RO Memory-Like T Cells, and CD4 T Cells Are Associated with Protection against Malaria Infection in Pregnancy

et al. 2008

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Previous studies have shown that gamma interferon (IFN-␥) production in the placenta is associated with protection against placental malaria. However, it remains unknown which IFN-␥-producing cell subpopulations are involved in this protection and whether the cellular immune components of protection are the same in the peripheral and the placental blood compartments. We investigated cell subpopulations for CD4, CD8, and CD45RO memory-like T cells and CD56 ؉ /CD3 ؊ natural killer (NK) cells and for IFN-␥ production by these cells in maternal peripheral and placental intervillous blood in relation to the status of malaria infection in pregnancy. Of 52 human immunodeficiency virus-negative enrolled pregnant women residing in Western Kenya, 20 had placental parasitemia. We found that the percentages of CD45RO memory-like and CD4 T cells were significantly higher in the periphery than in the placenta, while the CD56/CD3؊ NK-cell percentage was higher in the placenta than in the periphery, suggesting differences in immune cell profiles between the two blood compartments. Furthermore, the percentages of peripheral CD45RO memory-like and CD4 T cells were significantly elevated in aparasitemic women compared to levels in the parasitemic group, with aparasitemic multigravid women having the highest percentages of CD45RO memory-like and CD4 T cells. In contrast, at the placental level, IFN-␥ production by innate NK cells was significantly increased in aparasitemic women compared to parasitemic women, regardless of gravidity. These results suggest that the elevated IFN-␥-producing NK cells in the placenta and CD45RO memory-like and CD4 T cells in peripheral blood may be involved in protection against malaria infection in pregnancy.In regions where malaria is endemic, nonpregnant women with antimalarial immunity become more susceptible to infection during gestation than before pregnancy (3). In particular, they become at risk for placental parasitization, the placenta being the preferential site for parasite accumulation. The resulting placental malaria (PM) infection has severe consequences for both mother and child. Depending on transmission intensity, the public health consequences of malaria in pregnancy are varied. In low transmission settings, malaria infection increases the risk of maternal illness and fetal loss. In higher transmission areas, pregnant women are often asymptomatically infected but suffer preterm labor and maternal anemia and produce low-birth-weight infants who are at subsequent increased risk of neonatal and postneonatal mortality (17). In regions of intense malaria transmission, adverse consequences of malaria during pregnancy affect predominantly primigravid and secundigravid women; multigravid women are relatively less susceptible. This is true only among human immunodeficiency virus (HIV)-negative women.Previous immunological investigations in pregnant women from regions where malaria is holoendemic have revealed an increasing development of specific humoral and cellular immune responses over suc...

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Section: Investigations Of Cd4contrasting

confidence: 99%

Elevated Gamma Interferon-Producing NK Cells, CD45RO Memory-Like T Cells, and CD4 T Cells Are Associated with Protection against Malaria Infection in Pregnancy

et al. 2008

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“…One report similarly described a decreased expression of HLA-G in extravillous cytotrophoblast of term placenta infected with Plasmodium falciparum. [81] However, some controversies dealing with HLA-G functionality still persist. One report, for instance, concluded that no functional effects of HLA-G were found on freshly isolated first-trimester dNK cells.…”

Section: Discussionmentioning

confidence: 99%

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely vascular remodeling

Bouteiller¹

2015

Biomed J

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Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data. Membrane-bound and soluble HLA-G isoforms, either as b2-microglobulin-free or -associated as monomers or dimers, are expressed by different trophoblast subpopulations, the only fetal-derived cells that are directly in contact with maternal cells (maternal-

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“…If women could stimulate immediate IFN- γ release, they were able to control parasitaemia more effectively [167]. Unfortunately, this study only looked at women with favourable birth outcomes, and high numbers of NK cells have previously been associated with poor outcomes [174]. Whether or not this is related to the concentration of IFN- γ rather than to the number of cells remains to be seen.…”

Section: What Other Immune Mechanisms Are Involved In Pm?mentioning

confidence: 99%

Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response toPlasmodium falciparumVAR2CSA-Expressing Parasites

Kane

Taylor‐Robinson

2011

Malaria Research and Treatment

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Pregnancy-associated malaria, a manifestation of severe malaria, is the cause of up to 200,000 infant deaths a year, through the effects of placental insufficiency leading to growth restriction and preterm delivery. Development of a vaccine is one strategy for control.Plasmodium falciparum-infected red blood cells accumulate in the placenta through specific binding of pregnancy-associated parasite variants that express the VAR2CSA antigen to chondroitin sulphate A on the surface of syncytiotrophoblast cells. Parasite accumulation, accompanied by an inflammatory infiltrate, disrupts the cytokine balance of pregnancy with the potential to cause placental damage and compromise foetal growth. Multigravid women develop immunity towards VAR2CSA-expressing parasites in a gravidity-dependent manner which prevents unfavourable pregnancy outcomes. Although current vaccine design, targeting VAR2CSA antigens, has succeeded in inducing antibodies artificially, this candidate may not provide protection during the first trimester and may only protect those women living in areas endemic for malaria. It is concluded that while insufficient information about placental-parasite interactions is presently available to produce an effective vaccine, incremental progress is being made towards achieving this goal.

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Less HLA-G Expression in Plasmodium falciparum-Infected Third Trimester Placentas is Associated with More Natural Killer Cells

Cited by 24 publications

References 34 publications

Elevated Gamma Interferon-Producing NK Cells, CD45RO Memory-Like T Cells, and CD4 T Cells Are Associated with Protection against Malaria Infection in Pregnancy

Elevated Gamma Interferon-Producing NK Cells, CD45RO Memory-Like T Cells, and CD4 T Cells Are Associated with Protection against Malaria Infection in Pregnancy

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely vascular remodeling

Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response toPlasmodium falciparumVAR2CSA-Expressing Parasites

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