24Background 25 Sleep and physical activity are modifiable behaviors that play an important role in preventing 26 overweight, obesity, and metabolic health problems. Studies of the association between 27 concurrent objective measures of sleep, physical activity, and metabolic risk factors among 28 adolescents are limited. 29 Objective 30The aim of the study was to examine the association between metabolic risk factors and 31 objectively measured school day physical activity and sleep duration, quality, onset, and 32 variability in adolescents. 34 We measured one school week of free-living sleep and physical activity with wrist actigraphy 35 in 252 adolescents (146 girls), aged 15.8±0.3 years. Metabolic risk factors included body mass 36 index, waist circumference, total body and trunk fat percentage, resting blood pressure, and 37 fasting glucose and insulin levels. Multiple linear regression adjusted for sex, parental 38 education, and day length was used to assess associations between metabolic risk factors and 39 sleep and activity parameters.
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Materials and Methods40
Results
41On average, participants went to bed at 00:22±0.88 hours and slept 6.2±0.7 hours/night, with 42 0.83±0.36 hours of awakenings/night. However, night-to-night variability in sleep duration 43 (0.87±0.57 hours) and bedtime (0.79±0.58 hours) was considerable. Neither average sleep 44 duration nor mean bedtime was associated with any metabolic risk factors. However, greater 45 night-to-night variability in sleep duration was associated with higher total body (β=1.9±0.9 3 46 %/h, p=0.03) and trunk fat percentage (β=1.6±0.7 %/h, p=0.02), poorer sleep quality (more 47 hours of awakening) was associated with higher systolic blood pressure (β=4.9±2.2 mmHg/h, 48 p=0.03), and less physical activity was associated with higher trunk fat percentage (p=0.04) and 49 insulin levels (p=0.01).
50
Conclusion
51Greater nightly variation in sleep, lower sleep quality, and less physical activity was associated 52 with a less favorable metabolic profile in adolescents. These findings support the idea that, 53 along with an adequate amount of sleep and physical activity, a regular sleep schedule is 54 important to the metabolic health of adolescents. 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 4 70 71The prevalence of overweight in the world has nearly tripled from 1975-2016, with over 72 39% of adults and 18% of children and adolescents being overweight or obese [1]. Greater total 73 body and central adiposity is associated with increased risk of cardio-metabolic comorbidities, 74 such as hypertension and diabetes [2, 3]. Prevalence of metabolic syndrome is high among 75 obese children and adolescents and increases with higher central obesity [4]. Along with diet, 76 sleep and physical activity have been identified as important modifiable risk factors implicated 77 in the development of overweight, obesity, and metabolic health problems [5]. 78 The importance of adequate sleep for health and daily functioning in adolescents is well 79 established [...