Lesser Investigated Natural Ingredients for the Management of Obesity

Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Gnanamani, Muthuraman; Mundkur, Lakshmi

doi:10.3390/nu13020510

Cited by 12 publications

(4 citation statements)

References 129 publications

(128 reference statements)

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“…Oral supplementation could affect the signals associated with lipid catabolism, lipolysis, mitochondria biogenesis, and uncoupling protein 1 (UCP1)-positive cells in the adipose tissues and contribute to managing obesity and metabolic syndrome [ 18 ]. The qPCR was performed to examine if RF feeding could regulate the lipid catabolism genes, including thermogenic signaling in the BAT, WAT, and liver.…”

Section: Resultsmentioning

confidence: 99%

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

et al. 2022

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Ribes fasciculatum has been consumed as a food and as a traditional medicine for treating autoimmune diseases and aging in diverse countries. A previous study showed that a mixture of Ribes fasciculatum and Cornus officinalis prohibited adipocyte differentiation and lipid accumulation in preadipocytes and suppressed diet-induced obesity. Nevertheless, the mechanism of R. fasciculatum to regulate energy homeostasis solely through thermogenic signaling remains unclear. Thus, we investigated its effects on energy homeostasis using R. fasciculatum fed to C57BL/6 mice with a 45% high-fat diet. Chronic consumption of R. fasciculatum decreased the body weight of obese mice with increasing food intakes and improved metabolic-syndrome-related phenotypes. Therefore, we further tested its thermogenic effects. Cold chamber experiments and qPCR studies indicated that R. fasciculatum elevated thermogenic signaling pathways, demonstrated by increased body temperature and uncoupling protein 1 (UCP1) signaling in the white and brown adipose tissues. Afzelin is one major known compound derived from R. fasciculatum. Hence, the isolated compound afzelin was treated with preadipocytes and brown adipocytes for cell viability and luciferase assay, respectively, to further examine its thermogenic effect. The studies showed that the response of afzelin was responsible for cell viability and the increased UCP1. In conclusion, our data indicated that R. fasciculatum elevated peripheral thermogenic signaling through increased UCP1 via afzelin activation and ameliorated diet-induced obesity.

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Section: Resultsmentioning

confidence: 99%

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

et al. 2022

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“…However, for many patient sruggling with obesity, implemening and maintaining these changes is too challenging. A number of clinical trials have been undertaken among natural products for weight management with varying effectiveness [34]. The current review found that Ashwagandha, its active ingredients may have a role in obesity management.…”

Section: Discussionmentioning

confidence: 96%

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Nowak,

Bogusz,

Baran

et al. 2023

J Educ Health Sport

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Introduction and purpose: Ashwagandha (fam. Solanaceae) also known as Withania somnifera, is an herb commonly used in traditional Ayurvedic medicine. It is sometimes called Indian ginseng or winter cherry and it is used for its extensive health benefits for millennia as a Rasayana. Ashwagadha supplementation is playing an increasing role not only as an adaptogen, but is beneficial in the context of health in individuals struggling with obesity. This is a growing field of research and the aim of this brief review is to provide an update on the positive effects of Ashwagandha supplementation on the health of those dealing with obesity. Description of the state of knowledge: Ashwagandha has a wide range of positive effects, most common are sedative, anti-stress, immunomodulatory and anti-cancer effects. The literature also draws attention to other results such as binding insulin sensitivity, increasing endurance, effects on adipogenesis and lipogenesis. Ashwagandha lowers blood cortisol levels, inhibits fat accumulation and the expression of genes involved into excessive fat tissue accumulation. Summary: Regular intake of Ashwagandha is associated with health benefits in people struggling with obesity. As an adaptogen with adipogenic potential, Ashwagandha has great potential to participate in future adjunctive obesity therapy and the prevention of other similar and obesity-related diseases, but further research is needed in this area.

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“…The increase of free fatty acids and chronic overnutrition seem to induce lipotoxicity and endoplasmic reticulum stress. This inflammatory response might contribute to a blunted physiological response to leptin in obesity [ 60 ] even if overweight individuals have a higher circulating leptin level [ 61 ] throughout the circadian rhythm [ 62 ]. However, the daily variations in overweight individuals are smaller than those in normal-weight individuals.…”

Section: Discussionmentioning

confidence: 99%

Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Bouillon‐Minois

Trousselard²,

Torgerson

et al. 2021

Nutrients

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Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stress. Methods: PubMed, Cochrane Library, Embase, and ScienceDirect were searched to obtain all articles studying leptin levels after acute stress on 15 February 2021. We included articles reporting leptin levels before and after acute stress (physical or psychological) and conducted random effects meta-analysis (DerSimonian and Laird approach). We conducted Meta-regressions and sensitivity analyses after exclusion of groups outside the metafunnel. Results: We included seven articles—four cohort and three case-control studies—(28 groups) from 27,983 putative articles. Leptin levels decreased after the stress intervention (effect size = −0.34, 95%CI −0.66 to −0.02) compared with baseline levels, with a greater decrease after 60 min compared to mean decrease (−0.45, −0.89 to −0.01) and in normal weight compared to overweight individuals (−0.79, −1.38 to −0.21). There was no difference in the overweight population. Sensitivity analyses demonstrated similar results. Levels of leptin after stress decreased with sex ratio—i.e., number of men/women—(−0.924, 95%CI −1.58 to −0.27) and increased with the baseline levels of leptin (0.039, 0.01 to 0.07). Conclusions: Leptin is a biomarker of stress, with a decrease following acute stress. Normal-weight individuals and women also have a higher variation of leptin levels after stress, suggesting that leptin may have implications in obesity development in response to stress in a sex-dependent manner.

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Lesser Investigated Natural Ingredients for the Management of Obesity

Cited by 12 publications

References 129 publications

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

Benefits of Withania somnifera (Ashwagandha) supplementation in obesity

Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

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