Lesser-Known Enabling Technologies for Organic Synthesis

O’Brien, Matthew; Denton, Ross M.; Ley, Steven V.

doi:10.1055/s-0030-1259979

Cited by 25 publications

(9 citation statements)

References 78 publications

(83 reference statements)

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“…[10] Recently, ball-milling mechanochemistry, [11] as a solvent-free method for synthetic transformations has become an area of research interest due to its benefits over solutionbased methods. [12] Many advantages are associated during synthesis by mechanochemistry. [11d] This method has huge importance for green processes due to time efficiency, envi-ronmentally friendliness and inexpensive synthesis.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis

2015

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We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof‐of‐concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed under solvent‐free, metal‐free, mechanochemical (ball milling) and ambient laboratory conditions. Br+‐catalyzed oxidation of benzyl alcohols led to the product benzaldehydes and byproduct H+ which were further promoted as component and catalyst, respectively, for a cascade transformation to dihydropyrimidones within the same reaction pot. Remarkably, in solution, the reaction system could not be reproduced at room temperature even after 24 h.

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Section: Introductionmentioning

confidence: 99%

Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis

2015

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“…To overcome some of these inefficient practices, continuous processing methods such as flow chemistry [26–32] and other enabling technologies [16,33–35] are receiving increased attention.…”

Section: Reviewmentioning

confidence: 99%

Camera-enabled techniques for organic synthesis

Ley¹,

Ingham²,

O’Brien³

et al. 2013

Beilstein J. Org. Chem.

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SummaryA great deal of time is spent within synthetic chemistry laboratories on non-value-adding activities such as sample preparation and work-up operations, and labour intensive activities such as extended periods of continued data collection. Using digital cameras connected to computer vision algorithms, camera-enabled apparatus can perform some of these processes in an automated fashion, allowing skilled chemists to spend their time more productively. In this review we describe recent advances in this field of chemical synthesis and discuss how they will lead to advanced synthesis laboratories of the future.

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“…as alternative energy sources to replace common laboratory techniques [25]. Among them, especially mechanochemical synthesis [26–29] has gained popularity due to its advantage over conventional solution-based methods [30]. The process is highly beneficial as the solvent-free condition may make traditional workup superfluous [31–32].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemistry of supramolecules

Bose¹,

Mal²

2019

Beilstein J. Org. Chem.

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The urge to use alternative energy sources has gained significant attention in the eye of chemists in recent years. Solution-based traditional syntheses are extremely useful, although they are often associated with certain disadvantages like generation of waste as by-products, use of large quantities of solvents which causes environmental hazard, etc. Contrastingly, achieving syntheses through mechanochemical methods are generally time-saving, environmentally friendly and more economical. This review is written to shed some light on supramolecular chemistry and the synthesis of various supramolecules through mechanochemistry.

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Lesser-Known Enabling Technologies for Organic Synthesis

Abstract: In this review we summarize both new emerging technologies as well as some overlooked methods which are beneficial to organic synthesis chemists.

Cited by 25 publications

References 78 publications

Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis

Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis

Camera-enabled techniques for organic synthesis

Mechanochemistry of supramolecules

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