“…However, like in the present study, usually women with mitral stenosis are referred for cardiological follow-up only after the beginning of pregnancy. Facing these facts and the low incidence of complications observed when the balloon mitral valvulotomy technique is used during pregnancy [16][17][18][19][20][21][22][23] , this procedure should be seriously considered for the treatment of pregnant women with mitral stenosis and a greatly reduced mitral valve area, independently of their functional class, particularly if we take into account that acute lung edema can be the first clinical manifestation of mitral stenosis during pregnancy 10,11 . Unfortunately, we did not have the opportunity to eva- luate the influence of important covariables on the associations investigated in this study.…”