Lessons for the clinical nephrologist: an uncommon cause of rigors and chills on dialysis

Denecke, Morgan; Lal, Vatsal; Bean, K; Kidd, Jason

doi:10.1007/s40620-021-01242-4

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The etiology of the hypersensitivity reaction is not always clear. Depending on severity of hypersensitive reactions, dialysis treatments may or may not be discontinued [2,3]. Hypersensitivity reaction are classified as Type A and Type B reactions [2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on severity of hypersensitive reactions, dialysis treatments may or may not be discontinued [2,3]. Hypersensitivity reaction are classified as Type A and Type B reactions [2,[4][5][6]. Type A reactions begin in the first few minutes after initiation of dialysis, and they may be immunoglobulin E (IgE) dependent such as true anaphylactic reactions or IgE independent as anaphylactoid reactions [6].…”

Section: Introductionmentioning

confidence: 99%

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Hypersensitive Reactions During Hemodialysis Treatment: What Do We Need to Know?

Afsar,

Afsar

2024

Seminars in Dialysis

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Kidney replacement therapies (KRTs) including hemodialysis (HD) are one of the treatment options for most of the patients with end‐stage kidney disease. Although HD is vital for these patients, it is not hundred percent physiological, and various adverse events including hypersensitivity reactions may occur. Fortunately, these reactions are rare in total and less when compared to previous decades, but it is still very important for at least two reasons: First, the number of patients receiving kidney replacement treatment is increasing globally; and the cumulative number of these reactions may be substantial. Second, although most of these reactions are mild, some of them may be very severe and even lead to mortality. Thus, it is very important to have basic knowledge and skills to diagnose and treat these reactions. Hypersensitivity reactions can occur at any component of dialysis machinery (access, extracorporeal circuit, medications, etc.). The most important preventive measure is to avoid the allergen. However, even with very specific test, sometimes the allergen cannot be found. In mild conditions, HD can be contained with non‐specific treatment (topical creams, antihistaminics, corticosteroids). In more severe conditions, treatment must be stopped immediately, blood should not be returned to patient, drugs must be stopped, and rules of general emergency treatment must be followed.

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