Lessons from bone histomorphometry on the mechanisms of action of osteoporosis drugs

Zhou, Hua; Dempster, David W.

doi:10.1016/b978-0-12-813073-5.00081-2

Cited by 3 publications

(1 citation statement)

References 154 publications

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“…Il a été démontré que tous réduisaient le risque fracturaire. La réduction de ce risque varie de 30 à 70 % pour les fractures vertébrales, de 40 à 50 % pour les fractures de la hanche et de 15 à 20 % pour les autres sites fracturaires, selon l'agent thérapeutique [6]. Des essais cliniques et des études observationnelles, ont mis en évidence que certains patients subiront de nouvelles fractures au cours du traitement.…”

Section: B La Résistance Au Traitement Anti-ostéoporotiqueunclassified

La réponse inadéquate aux traitements anti-ostéoporotiques est liée à la persistance de la résorption osseuse chez les patients ostéoporotiques

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Fardellone

Cormier

et al. 2021

Revue du Rhumatisme

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Section: B La Résistance Au Traitement Anti-ostéoporotiqueunclassified

La réponse inadéquate aux traitements anti-ostéoporotiques est liée à la persistance de la résorption osseuse chez les patients ostéoporotiques

Léger

Fardellone

Cormier

et al. 2021

Revue du Rhumatisme

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Does adding exercise or physical activity to pharmacological osteoporosis therapy in patients with increased fracture risk improve bone mineral density and lower fracture risk? A systematic review and meta-analysis

Schumm,

Craige,

Arora

et al. 2023

Osteoporos Int

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This prospectively registered systematic review and meta-analysis examines whether exercise (EX) training has an additive effect to osteoanabolic and/or antiresorptive pharmacological therapy (PT) in people with osteoporosis on bone mineral density (BMD), bone turnover markers (BTMs), fracture healing, and fractures. Four databases (inception to 6 May 2022), 5 trial registries, and reference lists were searched. Included were randomized controlled trials comparing the effect of EX + PT vs. PT with regard to BMD, BTM, fracture healing, and fractures. Risk of bias was assessed using the Cochrane RoB2 and certainty of evidence by the GRADE approach. Random-effects meta-analysis with Hartung-Knapp-Sidik-Jonkman adjustment was used to estimate standardized mean differences and 95% confidence intervals. Out of 2593 records, five RCTs with 530 participants were included. Meta-analysis showed with very low certainty evidence and wide confidence intervals that EX + PT compared to PT had larger effect sizes for BMD at 12 months at the hip (SMD [95%CI]: 0.18 [− 1.71; 2.06], n = 3 studies), tibia (0.25 [− 4.85; 5.34], n = 2), lumbar spine (0.20 [− 1.15; 1.55], n = 4), and forearm (0.05 [− 0.35; 0.46], n = 3), but not femoral neck (− 0.03 [− 1.80; 1.75], n = 3). Furthermore, no improvement was revealed for BTM such as bone ALP (− 0.68 [− 5.88; 4.53], n = 3), PINP (− 0.74 [− 10.42; 8.93], n = 2), and CTX-I (− 0.69 [− 9.61; 8.23], n = 2), but with very wide confidence intervals. Three potentially relevant ongoing trials were identified via registries. No data were found for fracture healing or fracture outcomes. It remains unclear whether EX has an additive impact to PT in people with osteoporosis. High-quality, adequately powered, targetted RCTs are required. Protocol Registration PROSPERO CRD42022336132. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-023-06829-0.

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Anabolic Agents for Postmenopausal Osteoporosis: How Do You Choose?

Cosman

Dempster

2021

Curr Osteoporos Rep

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Lessons from bone histomorphometry on the mechanisms of action of osteoporosis drugs

Cited by 3 publications

References 154 publications

La réponse inadéquate aux traitements anti-ostéoporotiques est liée à la persistance de la résorption osseuse chez les patients ostéoporotiques

La réponse inadéquate aux traitements anti-ostéoporotiques est liée à la persistance de la résorption osseuse chez les patients ostéoporotiques

Does adding exercise or physical activity to pharmacological osteoporosis therapy in patients with increased fracture risk improve bone mineral density and lower fracture risk? A systematic review and meta-analysis

Anabolic Agents for Postmenopausal Osteoporosis: How Do You Choose?

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