Lessons from geographic mapping of IBD in France

Green, Christopher; Bernstein, Çharles N.

doi:10.1002/ibd.21115

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…These limitations have already been discussed in our previous papers 9, 11 . Moreover, in a recent paper concerning geographical mapping of IBD, Green and Bernstein suggest to use small geographical areas to minimise the misclassification of populations by risk categories 12 . However, the sun exposure data are available at the scale of ‘departments’ and not at a smaller scale.…”

Section: Discussionmentioning

confidence: 99%

“…9,11 Moreover, in a recent paper concerning geographical mapping of IBD, Green and Bernstein suggest to use small geographical areas to minimise the misclassification of populations by risk categories. 12 However, the sun exposure data are available at the scale of 'departments' and not at a smaller scale. In addition, the association between sun exposure and CD is not necessarily causal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low exposure to sunlight is a risk factor for Crohn’s disease

Nerich

Jantchou

Boutron‐Ruault

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low exposure to sunlight is a risk factor for Crohn’s disease

Nerich

Jantchou

Boutron‐Ruault

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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Répartition spatio-temporelle des cas de tuberculose dans la ville de Saint-Louis du Sénégal entre 2008–2011

Massenet

Fall²,

Diop

et al. 2013

Revue d'Épidémiologie et de Santé Publique

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Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada

Michel

St-Onge

Lowe

et al. 2010

International Journal of Health Geographics

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BackgroundCrohn's disease (CD) is clinically expressed as a chronic affection of the gastrointestinal tract currently known to have a multifactorial etiology involving a complex pathophysiological host response modulated by genetic susceptibilities, demographic determinants and environmental factors. With more than 20 cases per 100,000 person-years, the province of Quebec, Canada is among regions of the world with highest reported occurrence of CD in relation to other places where comparable estimates are available. This ecological study was designed to provide a medium-scale spatial exploration of CD incidence after accounting for the influence of known population and regional determinants. Health records of consulting patients in southern Quebec were compiled from 1995 to 2000 and used to estimate age and sex standardized rates per health area (n = 156). Various statistical models taking into account the regional effect of Jewish ethnicity, aboriginal ancestry, material deprivation, prescription for oral contraceptives, reportable enteric infection incidence, smoking as well as latitude and longitude locations were fitted.ResultsThe final regression model presented a coefficient of determination of 22.8% and there was evidence of an eastern trend in the residual incidence (p = 0.018). Overall, the smoothed residual incidence presented a heterogeneous spatial pattern with evidence of patches (multiple health areas) of high, low and contrasting values. Health areas with most extreme incidence residuals where also distributed over the whole province including one area in the metropolitan area of Montreal and others in surrounding areas.ConclusionsThese findings suggest that known populational and regional factors derived through census information only explain a limited fraction of the geographical variation of CD incidence and lead to speculate that the effects of these factors may be incompletely captured (imperfect construction of proxy variables) or that other important factors remain unmeasured. In this view, markers of genetic profiles of homogeneous sub-populations, and other factors linked to agroenvironmental microbial exposure should be further investigated. Once accounting for known factors, it would also be worth comparing adjacent geographical areas demonstrating abrupt changes in residual incidence rates to further explore effect linked to regional factors from those resulting from various reporting systems.

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Lessons from geographic mapping of IBD in France

Cited by 3 publications

References 14 publications

Low exposure to sunlight is a risk factor for Crohn’s disease

Low exposure to sunlight is a risk factor for Crohn’s disease

Répartition spatio-temporelle des cas de tuberculose dans la ville de Saint-Louis du Sénégal entre 2008–2011

Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada

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