Lessons from the canine <i>Oxtr</i> gene: populations, variants and functional aspects

Bence, Melinda; Marx, Peter W.; Szantai, Eszter; Kubinyi, Enikő; Rónai, Zsolt; Bánlaki, Zsófia

doi:10.1111/gbb.12356

Cited by 27 publications

(21 citation statements)

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“…Five novel (-213AG, -94TC, -74CG, -50CG, 19208AG) and three known (rs22927829, rs8679682, rs8679684) SNPs were found and genotyped in larger populations involving German Shepherds (N=71), Border Collies (N=104), Labrador-and Golden Retrievers (N=64), Beagles (N=29) and wolves (N=44). The results confirmed that the identified SNPs are polymorphic not only in the dog breeds, but also in wolves, however allele frequencies differed among the investigated breeds as well as between dogs and wolves.These results have recently been confirmed and extended(Bence et al, 2017) by investigating a large population involving nearly 700 dogs from 10 different breeds (Beagle, N=70; Border…”

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confidence: 57%

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The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris)

Kis

Ciobîcă

Topál

2017

Hormones and Behavior

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The oxytocin system has recently received increasing attention due to its effect on complex human behaviours. In parallel to this, over the past couple of decades, the human-analogue social behaviour of dogs has been intensively studied. Combining these two lines of research (e.g. studying the relationship between dog social behaviour and the oxytocin system) is a promising new research area. The present paper reviews the existing literature on how oxytocin is related to different aspects of human-directed social behaviour in dogs.

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confidence: 57%

“…breed effects. Some studies have already shown that different dog breeds differ in allele frequency for certain OXTR polymorphisms (Bence et al, 2016), and that these polymorphisms, as well as IN-OXT treatment can have differential effects in case of different breeds (Kis et al, 2014a;Kovács et al, 2016b).…”

Section: Discussionmentioning

confidence: 99%

The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris)

Kis

Ciobîcă

Topál

2017

Hormones and Behavior

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“…Specifically, whereas the pet dog population was heterogeneous with respect to breed, age and body size, the assistance dog population consisted entirely of young retriever dogs. Given potential for breed differences in OT genetics (Bence et al, 2016) future investigations of possible differences between pet and selectively bred working populations will benefit from designs controlling for these parameters.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Oxytocin, Vasopressin and Aggression in Domestic Dogs

MacLean

Gesquiere

Gruen

et al. 2017

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Abstract:Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP) -neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species -and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma. In Experiment 1 we evaluated behavioral and neuroendocrine differences between a population of pet dogs with a history of chronic aggression toward conspecifics and a matched control group. Dogs with a history of aggression exhibited more aggressive behavior during simulated encounters with conspecifics, and had lower free, but higher total plasma AVP than matched controls, but there were no group differences for OT. In Experiment 2 we compared OT and AVP concentrations between pet dogs and a population of assistance dogs that have been bred for affiliative and non-aggressive temperaments, and investigated neuroendocrine predictors of individual differences in social behavior within the assistance dog population.Compared to pet dogs, assistance dogs had higher free and total OT, but there were no differences in either measure for AVP. Within the assistance dog population, dogs who behaved more aggressively toward a threatening stranger had higher total AVP than dogs who did not. Collectively these data suggest that endogenous OT and AVP may play critical roles in shaping dog social behavior, including aspects of both affiliation and aggression.Keywords: oxytocin, vasopressin, aggression, dog, behavior All rights reserved. No reuse allowed without permission.(which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/151514 doi: bioRxiv preprint first posted online Jun. 18, 2017; MacLean 3Aggressive behavior in dogs is a serious concern for reasons related to both public health and animal welfare. In the United States it is estimated that dogs bite ~4.5 million Americans annually, with approximately half of these bites directed toward children (Centers for Disease Control and Prevention, 2003;Gilchrist, Sacks, White, & Kresnow, 2008). In addition to this impact on human lives, aggression (toward humans or other dogs) is also one of the most common reasons that dogs are relinquished to animal shelters (Salman et al., 1998), with ~2 million of these dogs being euthanized every year (Patronek, Glickman, Beck, McCabe, & Ecker, 1996). Despite these widely recognized concerns, we know relatively little about the biological factors underlying dog aggression.Previous studies on the biology of canine aggression have focused predominantly on the role of androgens and the serotonergic system. Although testosterone is positively associated with aggres...

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“…Specifically, whereas the pet dog population was heterogeneous with respect to breed, age and body size, the assistance dog population consisted entirely of young retriever dogs. Given potential for breed differences in OT genetics (Bence et al, 2016 ) future investigations of possible differences between pet and selectively bred working populations will benefit from designs controlling for these parameters. Similarly, many individuals in the assistance dog sample were intact at the time of testing, whereas all pet dogs were sterilized.…”

Section: Methodsmentioning

confidence: 99%

Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs

et al. 2017

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Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)—neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species—and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma. In Experiment 1 we evaluated behavioral and neuroendocrine differences between a population of pet dogs with a history of chronic aggression toward conspecifics and a matched control group. Dogs with a history of aggression exhibited more aggressive behavior during simulated encounters with conspecifics, and had lower free, but higher total plasma AVP than matched controls, but there were no group differences for OT. In Experiment 2 we compared OT and AVP concentrations between pet dogs and a population of assistance dogs that have been bred for affiliative and non-aggressive temperaments, and investigated neuroendocrine predictors of individual differences in social behavior within the assistance dog population. Compared to pet dogs, assistance dogs had higher free and total OT, but there were no differences in either measure for AVP. Within the assistance dog population, dogs who behaved more aggressively toward a threatening stranger had higher total AVP than dogs who did not. Collectively these data suggest that endogenous OT and AVP may play critical roles in shaping dog social behavior, including aspects of both affiliation and aggression.

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Lessons from the canine Oxtr gene: populations, variants and functional aspects

Cited by 27 publications

References 79 publications

The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris)

The effect of oxytocin on human-directed social behaviour in dogs (Canis familiaris)

Endogenous Oxytocin, Vasopressin and Aggression in Domestic Dogs

Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs

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