Lessons from the history of inorganic nanoparticles for inhalable diagnostics and therapeutics

Uskoković, Vuk

doi:10.1016/j.cis.2023.102903

Cited by 11 publications

(3 citation statements)

References 329 publications

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“…A series of talks presented at the special symposium on MXenes in living systems described the newest results on characterization of this relatively new type of material for versatile biological responses. As usually happens in the early stages of analysis of such responses [68], results were contradictory. On one hand, Lucia Delogu from the University of Padua in Italy intended to report on the excellent biological and immune compatibility of MXenes [69] as well as the ability to inhibit monocytes and reduce the release of pro-inflammatory cytokines, alongside the antiviral activity of 2D carbides, nitrides, and carbonitrides as exemplary MXenes against SARS-CoV-2.…”

Section: Regular Oral Presentationsmentioning

confidence: 98%

YUCOMAT 2023: An International Advisory Board Member’s Digest

Uskoković

2023

The 24th Yugoslav Conference on Materials

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Section: Regular Oral Presentationsmentioning

confidence: 98%

YUCOMAT 2023: An International Advisory Board Member’s Digest

Uskoković

2023

The 24th Yugoslav Conference on Materials

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“…Despite their intriguing properties, some of the most studied inorganic carriers for pulmonary applications have been associated with the largest records of pulmonary toxicity. For this reason, they will be not the object of this review [ 8 ]. An exhaustive review on the topic highlighting the potential for the future prospective of inorganic materials for inhalation are reported [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, they will be not the object of this review [ 8 ]. An exhaustive review on the topic highlighting the potential for the future prospective of inorganic materials for inhalation are reported [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development Perspectives

Costabile,

Conte,

Brusco

et al. 2024

Pharmaceutics

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Nowadays, the interest in research towards the local administration of drugs via the inhalation route is growing as it enables the direct targeting of the lung tissue, at the same time reducing systemic side effects. This is of great significance in the era of nucleic acid therapeutics and personalized medicine for the local treatment of severe lung diseases. However, the success of any inhalation therapy is driven by a delicate interplay of factors, such as the physiochemical profile of the payload, formulation, inhalation device, aerodynamic properties, and interaction with the lung fluids. The development of drug delivery systems tailored to the needs of this administration route is central to its success and to revolutionize the treatment of respiratory diseases. With this review, we aim to provide an up-to-date overview of advances in the development of nanoparticulate carriers for drug delivery to the lung tissue, with special regard concerning lipid and polymer-based nanocarriers (NCs). Starting from the biological barriers that the anatomical structure of the lung imposes, and that need to be overcome, the current strategies to achieve efficient lung delivery and the best support for the success of NCs for inhalation are highlighted.

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