INTRODUCTIONFood insecurity remains an underrecognized social determinant of health. 1-3 In 2017, approximately 11.8% of US households were food insecure. These households included approximately 40 million individuals. 4 The percentage of foodinsecure households is higher among racial/ethnic minorities, single-parent and low-income households, and individuals with low levels of education. 4 Research establishing the relationships between food insecurity and many adverse health outcomes, including chronic conditions such as diabetes, is relatively mature. 5-7 However, to the best of our knowledge, the association between food insecurity and cancer outcomes remains poorly understood. In this commentary, we briefly review studies examining the relationship between food insecurity and chronic illness, particularly cancer; postulate potential mechanisms for this correlation; suggest opportunities for screening and the subsequent management of food insecurity in the cancer clinical setting; and identify areas for further research.