Abstract.[Purpose] The purpose of this study was to compare the strength and endurance between open and closed kinematic chain exercises after anterior cruciate ligament reconstruction.[Subjects] Sixty-two subjects actively participating in rehabilitation for anterior cruciate ligament reconstruction for the last 3 month were chosen. Twenty-six subjects were excluded and consequently, the data of 36 subjects were analyzed. The participants were randomly divided into 2 groups for open or closed kinematic chain exercise. [Methods] Open or closed kinematic chain exercises were performed under direct supervision of 3 physical therapists for 30 minutes per session, 3 times a week for 12 weeks. Before and after the intervention, isokinetic strength, endurance, and squat strength were tested. [Results] In the comparison of the before and after exercise results, all variables showed significant differences. Open kinematic chain exercises resulted in a significantly greater gain in isokinetic strength and endurance of the extensor muscles than the closed kinematic chain exercises. [Conclusion] Open kinematic chain exercise is helpful for the development of strength and endurance of the knee extensor mechanism after anterior cruciate ligament reconstruction, and can be used effectively in a rehabilitation program.