Since the 20th century, health care institutions have used morbidity and mortality conferences (MMCs) as a forum to discuss complicated cases and fatalities to capitalize on lessons learned. Medical technology, health care processes, and the teams who provide care have evolved over time, but the format of the MMC has remained relatively unchanged. The present article outlines 5 key areas for improvement within the MMC along with prescriptive and actionable recommendations for mitigating these challenges. This work incorporates the contributions of numerous researchers and practitioners from the educational, training, debrief, and health care fields. With the best practices and lessons learned from various domains in mind, we recommend optimizing the MMC by (1) encouraging a culture that leverages expertise from multiple sources, (2) allocating ample time for innovative thinking, (3) using a global approach that considers individual, team, and system-level factors, (4) leveraging learnings from errors as well as near misses, and (5) promoting communication, innovative thinking, and actionable planning. The 5 evidence-based recommendations herein serve to ensure that MMCs are structured learning events that promote, encourage, and support safe, reliable care. Furthermore, the outlined recommendations seek to capitalize upon the MMC's opportunity to engage early discovery as well as proactive risk assessment and action-oriented solutions.B ecause of the prevalence of adverse events, the health care sector has made efforts to improve patient safety and quality care. The morbidity and mortality conference (MMC) is a forum to improve patient care through the disclosure and review of error and near-miss events by analyzing errors to gain insights and extract knowledge to improve care processes and outcomes. 1,2 To elaborate further, MMCs are traditionally regularly scheduled meetings in which select patient case studies and provider-raised issues are reviewed to (1) determine the appropriateness and evidence-base of the clinical provision of care when weighed against accepted best practices, (2) learn from patient cases where errors and complications occurred, and (3) determine whether future errors can be prevented or mitigated by adjusting actions and judgments. [3][4][5][6] Morbidity and mortality conferences are similar to debriefs (i.e., a forum of reflection and planning to improve performance 7 ); that is, participants in debriefs as well as MMCs reflect on a previous experience or case to identify actions, construct meaning, and uncover lessons that can be applied to improve outcomes. 7 Similar to MMCs, properly executed debriefs can improve performance of individuals and teams but only if they achieve their desired objectives. 7 Morbidity and mortality conferences are designed to educate the disciplines based on the experiences of a select, unfortunate few. 8,9 This education, ideally, leads to positively changed clinical practice, 10 and some advocate for increasing the frequency of the MMC. 11 Across health...