Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies

Chaudhury, Salma; Carr, Andrew

doi:10.1016/j.jse.2011.10.022

Cited by 37 publications

(26 citation statements)

References 68 publications

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“…In patients diagnosed before the age of 40, the relative risk of rotator cuff tear in second degree relatives was 3.66 and in third degree relatives 1.81 250 . The precise genetic pathways, linking genetic changes to rotator cuff tears, are not known, but seem to include gene changes that relate to apoptosis, metabolism, angiogenesis and the extracellular matrix 43 .…”

Section: Prevalence and Predisposing Factors For Rotator Cuff Tearmentioning

confidence: 99%

“…These histopathological features may in part explain the susceptibility of the degenerative cuff to atraumatic defects or avulsions after very minor trauma. The main causative factors, and their pathways to a full-thickness cuff tear, are not known in detail and are likely multifactorial, involving extracellular matrix, cellular metabolism and vascularity 43 .…”

Section: Intrinsic Changes In Torn Rotator Cuff Tendonsmentioning

confidence: 99%

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Rotator Cuff Tears : Short- and long-term aspects on treatment outcome

Ranebo

2020

Linköping University Medical Dissertations

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Section: Prevalence and Predisposing Factors For Rotator Cuff Tearmentioning

confidence: 99%

Section: Intrinsic Changes In Torn Rotator Cuff Tendonsmentioning

confidence: 99%

Rotator Cuff Tears : Short- and long-term aspects on treatment outcome

Ranebo

2020

Linköping University Medical Dissertations

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“…Often, tendinopathy is used synonymously with tendinitis and tendinosis, but the last-mentioned terms may also be reserved for tendons with histopathologic findings[1]. Tendon specimens from humans and animals with tendinopathy often show histopathologic changes, which may precondition the tendon to rupture[2–5]. Clinical manifestations suspected to reflect rotator cuff tendon alterations (e.g.…”

Section: Introductionmentioning

confidence: 99%

Proteomics Perspectives in Rotator Cuff Research: A Systematic Review of Gene Expression and Protein Composition in Human Tendinopathy

et al. 2015

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BackgroundRotator cuff tendinopathy including tears is a cause of significant morbidity. The molecular pathogenesis of the disorder is largely unknown. This review aimed to present an overview of the literature on gene expression and protein composition in human rotator cuff tendinopathy and other tendinopathies, and to evaluate perspectives of proteomics – the comprehensive study of protein composition - in tendon research.Materials and MethodsWe conducted a systematic search of the literature published between 1 January 1990 and 18 December 2012 in PubMed, Embase, and Web of Science. We included studies on objectively quantified differential gene expression and/or protein composition in human rotator cuff tendinopathy and other tendinopathies as compared to control tissue.ResultsWe identified 2199 studies, of which 54 were included; 25 studies focussed on rotator cuff or biceps tendinopathy. Most of the included studies quantified prespecified mRNA molecules and proteins using polymerase chain reactions and immunoassays, respectively. There was a tendency towards an increase of collagen I (11 of 15 studies) and III (13 of 14), metalloproteinase (MMP)-1 (6 of 12), -9 (7 of 7), -13 (4 of 7), tissue inhibitor of metalloproteinase (TIMP)-1 (4 of 7), and vascular endothelial growth factor (4 of 7), and a decrease in MMP-3 (10 of 12). Fourteen proteomics studies of tendon tissues/cells failed inclusion, mostly because they were conducted in animals or in vitro.ConclusionsBased on methods, which only allowed simultaneous quantification of a limited number of prespecified mRNA molecules or proteins, several proteins appeared to be differentially expressed/represented in rotator cuff tendinopathy and other tendinopathies. No proteomics studies fulfilled our inclusion criteria, although proteomics technologies may be a way to identify protein profiles (including non-prespecified proteins) that characterise specific tendon disorders or stages of tendinopathy. Thus, our results suggested an untapped potential for proteomics in tendon research.

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“…1 Specific genotypes might be more susceptible to failure of the homeostasis of rotator cuff tendon matrix, which may lead to accelerated mechanical failure of specific zones of the rotator cuff tendons. [2][3][4] This normal ageing phenomenon is not necessarily painful. [5][6][7] The majority of rotator cuff tears (RCTs), particularly those in the elderly, are asymptomatic, suggesting that the shoulder has a high capacity for adaptation to changing biomechanics provided that the changes are slow.…”

Section: Introductionmentioning

confidence: 99%

Assessment and treatment strategies for rotator cuff tears

2014

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Tears of the rotator cuff are common and becoming an increasingly frequent problem. There is a vast amount of literature on the merits and limitations of the various methods of clinical and radiological assessment of rotator cuff tears. This is also the case with regard to treatment strategies. Certain popular beliefs and principles practiced widely and the basis upon which they are derived may be prone to inaccuracy. We provide an overview of the historical management of rotator cuff tears, as well as an explanation for how and why rotator cuff tears should be managed, and propose a structured methodology for their assessment and treatment.

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Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies

Cited by 37 publications

References 68 publications

Rotator Cuff Tears : Short- and long-term aspects on treatment outcome

Rotator Cuff Tears : Short- and long-term aspects on treatment outcome

Proteomics Perspectives in Rotator Cuff Research: A Systematic Review of Gene Expression and Protein Composition in Human Tendinopathy

Assessment and treatment strategies for rotator cuff tears

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