Let's get loud: Amplifying female voices in sepsis research

Fitzgerald, Julie C; Reddy, Anireddy R; Woods-Hill, Charlotte

doi:10.1016/j.ebiom.2022.104370

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Systematic female under-representation in sepsis studies led to unexplored sex differences in sepsis host response and limitation to clinical translation [72]. Therefore, this manuscript questioned the generalizability of the strong recommendation for NE administration in septic shock and advocated for methodical SGBA.…”

Section: Discussionmentioning

confidence: 99%

Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?

Perna,

Raparelli,

Tordo Caprioli

et al. 2024

Microorganisms

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Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43.2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines.

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Section: Discussionmentioning

confidence: 99%

Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?

Perna,

Raparelli,

Tordo Caprioli

et al. 2024

Microorganisms

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Emerging paradigms in sepsis

Vincent¹

2022

eBioMedicine

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Global analysis of vasoactive agents in septic shock management: Exploring trends and bridging knowledge gaps

Sharifan

2024

J Transl Crit Care Med

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Background: The swift administration of vasoactive agents is essential for effectively managing septic shock. However, the unavailability of norepinephrine—the primary recommended agent—in certain clinical settings necessitates the exploration of alternative solutions. This study aimed to identify both the key focus areas and the under-researched aspects related to this topic. Methods: The Scopus database was searched from inception until August 2, 2024, using a comprehensive list of keywords related to the topics of “septic shock”, “vasopressors”, and “hypotension”. Articles lacking original data, namely narrative reviews, errata, corrections, and conference papers, were excluded from the analysis. No language restrictions were applied. The retrieved search results were examined for publication and citation trends, international contributions by countries and institutions, keyword usage, and funding sources. Data visualization was accomplished using VOSviewer, the built-in Scopus analyzer, the bibliometrix R package, and Microsoft Excel. Results: A total of 7474 publications were retrieved. These studies were published between 1958 and 2024, with the year 2022 representing the highest number of publications, and 2016 having the most citations. While publications had raised until 2022 and dwindled since then, citations had fluctuating patterns throughout the years. The research landscape was marked by contributions from 207 countries, with 160 institutions publishing at least 22 studies each. The United States emerged as the leader in both publications and international collaborations in this field, followed by France, the United Kingdom, China, and Germany. Notably, all of the top 20 countries in terms of publication volume were classified as high-income or upper-middle-income nations, except India. This disparity can largely be explained by the differences in funding allocated to studies in these countries. Furthermore, 28,442 keywords relevant to this topic were collected. The demographic representation in the studies showed a predominance of males and older adults compared to their counterparts and a significant proportion of the studies were clinical investigations. Among the various vasopressors examined, terlipressin, angiotensin II, methylene blue, and selepressin were identified as the least studied agents. Conclusion: Consensus definitions and statements in critical care, particularly for controversial topics, are essential for enhancing communication and improving patient care. There is a need for prioritized research and funding in the Global South regarding enhanced septic shock management. Further studies on vasoconstrictor agents with limited evidence are warranted to strengthen the body of knowledge in this area.

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Let's get loud: Amplifying female voices in sepsis research

Cited by 3 publications

References 10 publications

Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?

Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?

Emerging paradigms in sepsis

Global analysis of vasoactive agents in septic shock management: Exploring trends and bridging knowledge gaps

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