Let's have a serious discussion of nanopharmacology and homeopathy

Ullman, Dana

doi:10.1096/fj.06-1205ufm

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…Ullman suggested that homeopathic medicine could belong to nanopharmacology. 66 Using probing tools of nanoscience, many independent research groups confirmed that nanoparticles are present in ultra-high dilutions used as medicines in homeopathy. [23][24][25][26][27]67,68 The vigorous shaking process used in homeopathy increases the water pressure in the glass bottle substantially.…”

Section: How Ultra-high Dilutions May Work As Nanomedicinesmentioning

confidence: 99%

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Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Ullman¹

2021

Dose-Response

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Serially diluted succussed solutions of a suitable drug/toxic substance can exhibit physicochemical and biological properties even far beyond Avogadro’s limit defying conventional wisdom. They can show hormesis, and homeopathy uses them as medicines. Many studies confirm that they can have an impact on gene expression different than controls. Water in the exclusion zone phase can have memory but for a short period. However, the nanoparticle as the physical substrate can hold information. Nanoparticle and exclusion zone duo as nanoparticle-exclusion zone shell can provide a prolonged memory. The Nanoparticle-Exclusion Zone Shell Model may be an important step toward explaining the nature and bioactivity of serially diluted succussed solutions used as homeopathic medicines. This model may also provide insight into the workings of hormesis. Hormesis is the primary phenomenon through which homeopathic phenomenon may have evolved exhibiting the principle of similars. Hahnemann exploited it to establish homeopathy. The nanoparticle-exclusion zone shells present in the remedy, selected on the principle of similars, can be patient-specific nanoparticles in a symptom syndrome-specific manner. They can carry the drug-specific information for safer clinical applications in an amplified form for high yielding. It suggests homeopathy is a type of nanopharmacology.

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Section: How Ultra-high Dilutions May Work As Nanomedicinesmentioning

confidence: 99%

Section: How Ultra-high Dilutions May Work As Nanomedicinesmentioning

confidence: 99%

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Ullman¹

2021

Dose-Response

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“…Homeopathy claims this in favor (Kayne, 2006). Ullman (2006) envisioned homeopathy as belonging to nanopharmacology. Anick and Ives (2007) proposed a hypothesis suggesting that silica or its nanoparticles may play an important role in homeopathy.…”

Section: New Scientific Understandingmentioning

confidence: 99%

Untitled

2020

WATER

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To understand evolution better, biologists should take into account the development of an organism's reaction to stressors (i.e.,the secondary action of a stressor) during development, and the subtle role it plays. Hormesis and homeopathic phenomena are just names to classify such secondry properties. These phenomena exploit the secondary action, below that of a pharmacological of toxin dose in a beneficial fashion. An intriguing examination of the biological behavior of the secondary action leads to the proposed theory. dilutions. Experimental support is emerging for this theory, and some suggestions have been given for testing and verification. As this theory concerns the evolution of the earliest medicine with an intrinsic role in the evolutionary process, it could influence the whole field of medical science.

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“…Some studies showing these particles and their putative hormetic effects are well described in the literature. [41][42][43] Another hypothesis remains to be checked in the future: that the capacity of water itself acts as information carrier, based on electromagnetic properties derived from its dipole behavior. [44][45][46][47][48] Alternatively, the participation of both elements together-water and particles, mixed in complex nano-structures that are almost impossible to separate in nature-could elicit some biological effect.…”

Section: Discussionmentioning

confidence: 99%

Biological Actions, Electrical Conductance and Silicon-Containing Microparticles of Arsenicum Album Prepared in Plastic and Glass Vials

et al. 2018

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Introduction According to the “silica hypothesis” formulated to explain homeopathy, the information of starting materials would be transferred to cells by silica nanoparticles detached from the glassware walls by serial dilution and agitation through epitaxy. We compared the biological activity, electrical current and silicon microparticle content (by means of scanning electron microscopy/energy-dispersive X-ray spectroscopy) of high dilutions (HDs) of arsenic prepared in plastic and glass vials to investigate the role of silica in their biological effects in vitro. Materials and Methods Co-cultures of macrophages and yeast (Saccharomyces cerevisiae) were treated with different HDs of arsenic prepared in plastic and glass vials. Macrophage morphology, phagocytosis index, nitric oxide (NO), and cytokine production were evaluated. Results Measurable amounts of silicon microparticles were detected only in the HDs prepared in glass vials, but ultra-centrifugation eliminated them. Specific and non-specific results were observed. Non-specific pro-inflammatory effects were seen in all dilutions prepared in plastic vials, including elevation of pro-inflammatory cytokines, NO and macrophage phagocytic index. Only the 200th centesimal dilution of arsenic produced specific decrease in interleukin-6 production in macrophages, and it was independent of the vial type or the presence of microparticles of silica in the medicine samples. The nature of the vials had an impact on the electric flow in the respective fluids. Conclusion The non-specific, pro-inflammatory effects might be attributed to organic residuals detached from the vials' plastic walls during manipulation. Instead, specific silica-independent effects of the homeopathic medicine can be attributed to the decrease of interleukin-6 after treatment with the 200th centesimal dilution of arsenic.

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Let's have a serious discussion of nanopharmacology and homeopathy

Cited by 8 publications

References 9 publications

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

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Biological Actions, Electrical Conductance and Silicon-Containing Microparticles of Arsenicum Album Prepared in Plastic and Glass Vials

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