Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

Waldbaur, Ansgar; Rapp, Holger; Länge, Kerstin; Rapp, Bastian E.

doi:10.1039/c1ay05253e

Cited by 339 publications

(324 citation statements)

References 263 publications

(235 reference statements)

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“…The utilization of numerous thermoplastics and other polymers in one-step manufacturing such as FDM technology [18] and newer 3D printing platforms such as laser-adopted stereolithography, Digital Wax Systems (DWS) which allows the use of fine materials and materials with different chemical potentially providing opportunities for the use of more hydrophilic materials to be used to develop miniaturized vessels for ELISAs in the future.…”

Section: Discussionmentioning

confidence: 99%

“…The ease of use of various design drafting programs such computer aided design (CAD) software and the parallel development of 3D printing technologies with .STL (Standard Tessellation Language or STereoLithography) file formats as a link with 3D printers [17] has provided room for the rapid development of various prototypes and for easy and rapid design readjustment to be made following early assessments [18,19]. These rapid cycles of designing-prototype development-assessment and feedback are important considerations in the development of biomedical devices including those with potential of use in immunoassays.…”

mentioning

confidence: 99%

“…These rapid cycles of designing-prototype development-assessment and feedback are important considerations in the development of biomedical devices including those with potential of use in immunoassays. The use of wax-based polymers and other thermoplastics such as acrylonitrile-butadiene-styrene (ABS) and polycarbonate (PC) among others, which are easily fabricated, modified to become more hydrophilic enhancing surface-protein adsorption and disposable due to its low cost, are important aspects in the development of ELISA-based systems [5,11,14,[18][19][20][21][22][23][24]. The potential of such fabrication technologies in the development of diagnostics for infectious and other diseases and its potential impact in improving disease diagnosis, treatment, care and support, and prevention must not be excluded [25,26].…”

mentioning

confidence: 99%

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Increased sensitivity of 3D-Well enzyme-linked immunosorbent assay (ELISA) for infectious disease detection using 3D-printing fabrication technology

Singh

Shimojima

Fukushi

et al. 2015

BME

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Abstract. Enzyme-linked Immunosorbent Assay or ELISA -based diagnostics are considered the gold standard in the demonstration of various immunological reaction including in the measurement of antibody response to infectious diseases and to support pathogen identification with application potential in infectious disease outbreaks and individual patients' treatment and clinical care. The rapid prototyping of ELISA-based diagnostics using available 3D printing technologies provides an opportunity for a further exploration of this platform into immunodetection systems. In this study, a '3D-Well' was designed and fabricated using available 3D printing platforms to have an increased surface area of more than 4 times for protein-surface adsorption compared to those of 96-well plates. The ease and rapidity in designing-product developmentfeedback cycle offered through 3D printing platforms provided an opportunity for its rapid assessment, in which a chemical etching process was used to make the surface hydrophilic followed by validation through the diagnostic performance of ELISA for infectious disease without modifying current laboratory practices for ELISA. The higher sensitivity of the 3D-Well (3-folds higher) compared to the 96-well ELISA provides a potential for the expansion of this technology towards miniaturization platforms to reduce time, volume of reagents and samples needed for laboratory or field diagnosis of infectious diseases including applications in other disciplines.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Increased sensitivity of 3D-Well enzyme-linked immunosorbent assay (ELISA) for infectious disease detection using 3D-printing fabrication technology

Singh

Shimojima

Fukushi

et al. 2015

BME

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“…The emergence of modern additive manufacturing resources facilitates innovative solutions and the ability to evolve prototypes at affordable costs (Begolo et al, 2014;Symes et al, 2012;Comina et al, 2014aComina et al, , 2014bShallan et al, 2014;Wang et al, 2014;Waldbaur et al, 2011;Tseng et al, 2014;Tumbleston et al, 2015). A finger pump that exploits 3D printing technology is the pumping lid concept (Begolo et al, 2014).…”

Section: Transport / Reactionmentioning

confidence: 99%

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Comina

Suska

Filippini

2016

Biosensors and Bioelectronics

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Modern cell phones are a ubiquitous resource with a residual capacity to accommodate chemical sensing and biosensing capabilities. From the different approaches explored to capitalize on such resource, the use of autonomous disposable lab-on-a-chip (LOC) devices conceived as only accessories to complement cell phones underscores the possibility to entirely retain cell phones ubiquity for distributed biosensing. The technology and principles exploited for autonomous LOC devices are here selected and reviewed focusing on their potential to serve cell phone readout configurations. Together with this requirement, the central aspects of cell phones resources that determine their potential for analytical detection are examined. The conversion of these LOC concepts into universal architectures that are readable on unaccessorized phones is discussed within this context. (C) 2015 Elsevier B.V. All rights reserved.

Funding Agencies|Swedish Research Council (VR) [C0453801]; Carl Tryggers Foundation [CTS14140]

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“…Laser stereolithography, digital light processing, direct laser writing, two-photon polymerization and lithography-based ceramic manufacture are some examples of additive technologies working on the basis of additive photo-polymerization, which converts a liquid prepolymer or charged resin into a polymerized part or into a polymerized network with particles trapped inside. The liquid state procedure is also interesting for the development of 3D microfluidic systems and micro-vascular actuators [10,11], as the un-polymerized liquid resin or slurry can be more easily removed from the micrometric channels, than in the case of working with a powder-based processes. In consequence, its application to the development of microfluidic systems may constitute a promising approach towards new microsystems, obtained as single part fully integrated devices in just one manufacturing step.…”

Section: Introductionmentioning

confidence: 99%

Monolithic 3D labs- and organs-on-chips obtained by lithography-based ceramic manufacture

Lantada

Romero

Schwentenwein³

et al. 2017

Int J Adv Manuf Technol

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In this study, we present a novel approach for the design and development of three-dimensional monolithic ceramic microsystems with complex geometries and with potential applications in the biomedical field, mainly linked to labson-chips and organs-on-chips. The microsystem object of study stands out for its having a complex three-dimensional geometry, for being obtained as a single integrated element, hence reducing components, preventing leakage and avoiding post-processes, and for having a cantilever porous ceramic membrane aimed at separating cell culture chambers at different levels, which imitates the typical configuration of transwell assays. The design has been performed taking account of the special features of the manufacturing technology and includes ad hoc incorporated supporting elements, which do not affect overall performance, for avoiding collapse of the cantilever ceramic membrane during debinding and sintering. The manufacture of the complex three-dimensional microsystem has been accomplished by means of lithography-based ceramic manufacture, the additive manufacturing technology which currently provides the most appealing compromises between overall part size and precision when working with ceramic materials. The microsystem obtained provides one of the most remarkable examples of monolithic bio-microsystems and, to our knowledge, a step forward in the field of ceramic microsystems with complex geometries for lab-on-chip and organ-on-chip applications. Cell culture results help to highlight the potential of the proposed approach and the adequacy of using ceramic materials for biological applications and for interacting at a cellular level.

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Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

Cited by 339 publications

References 263 publications

Increased sensitivity of 3D-Well enzyme-linked immunosorbent assay (ELISA) for infectious disease detection using 3D-printing fabrication technology

Increased sensitivity of 3D-Well enzyme-linked immunosorbent assay (ELISA) for infectious disease detection using 3D-printing fabrication technology

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Monolithic 3D labs- and organs-on-chips obtained by lithography-based ceramic manufacture

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