Lethal COVID-19: Radiologic-Pathologic Correlation of the Lungs

Henkel, Maurice; Weikert, Thomas; Marston, Katharina; Schwab, Nathalie; Sommer, Gregor; Haslbauer, Jasmin D.; Franzeck, Fabian; Anastasopoulos, Constantin; Stieltjes, Bram; Michel, Anne; Bremerich, Jens; Menter, Thomas; Mertz, Kirsten D.; Tzankov, Alexandar; Sauter, Alexander

doi:10.1148/ryct.2020200406

Cited by 32 publications

(30 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few studies have correlated imaging findings in severe cases of COVID-19 pneumonia with histopathological findings [ 162 , 163 , 164 , 165 , 166 , 167 ]. This issue was investigated especially in case reports and case series mainly based on CT features described in ante-mortem or post-mortem examinations [ 163 , 164 , 165 , 166 ].…”

Section: Imaging and Histopathological Correlationsmentioning

confidence: 99%

“…This issue was investigated especially in case reports and case series mainly based on CT features described in ante-mortem or post-mortem examinations [ 163 , 164 , 165 , 166 ]. CT imaging findings such as GGO and consolidations usually correspond to histopathological examinations with diffuse alveolar damage (DAD) in different stages [ 162 , 163 , 164 , 165 , 166 ]. DAD is usually a nonspecific response of the lung to a multitude of injurious agents characterized by edema, endothelial and alveolar injury with hyaline membrane formation in the acute phase, and fibroblast proliferation and interstitial fibrosis in the organizing phase [ 162 , 163 ].…”

Section: Imaging and Histopathological Correlationsmentioning

confidence: 99%

“…Henkle et al [ 162 ] correlated the histopathological findings of 14 patients who died from COVID-19 confirmed by RT-PCR with ante-mortem CT examination. They found that the presence of GGO correlated with capillary dilation and congestion, interstitial edema, hemorrhage, and acute DAD.…”

Section: Imaging and Histopathological Correlationsmentioning

confidence: 99%

See 2 more Smart Citations

A Pictorial Review of the Role of Imaging in the Detection, Management, Histopathological Correlations, and Complications of COVID-19 Pneumonia

Brogna

Bignardi

Brogna³

et al. 2021

Diagnostics

View full text Add to dashboard Cite

Imaging plays an important role in the detection of coronavirus (COVID-19) pneumonia in both managing the disease and evaluating the complications. Imaging with chest computed tomography (CT) can also have a potential predictive and prognostic role in COVID-19 patient outcomes. The aim of this pictorial review is to describe the role of imaging with chest X-ray (CXR), lung ultrasound (LUS), and CT in the diagnosis and management of COVID-19 pneumonia, the current indications, the scores proposed for each modality, the advantages/limitations of each modality and their role in detecting complications, and the histopathological correlations.

show abstract

Section: Imaging and Histopathological Correlationsmentioning

confidence: 99%

Section: Imaging and Histopathological Correlationsmentioning

confidence: 99%

See 1 more Smart Citation

A Pictorial Review of the Role of Imaging in the Detection, Management, Histopathological Correlations, and Complications of COVID-19 Pneumonia

Brogna

Bignardi

Brogna³

et al. 2021

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Recently vascular changes other than PE have drawn attention [ 23 ]. Additional knowledge is, however, required and not yet available to confirm and better understand early observations.…”

Section: Introductionmentioning

confidence: 99%

Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Although vascular abnormalities are thought to affect coronavirus disease 2019 (COVID-19) patients’ outcomes, they have not been thoroughly characterized in large series of unselected patients. The Swiss national registry coronavirus-associated vascular abnormalities (CAVA) is a multicentric cohort of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who underwent a clinically indicated chest computed tomography (CT) aiming to assess the prevalence, severity, distribution, and prognostic value of vascular and non-vascular-related CT findings. Clinical outcomes, stratified as outpatient treatment, inpatient without mechanical ventilation, inpatient with mechanical ventilation, or death, will be correlated with CT and biological markers. The main objective is to assess the prevalence of cardiovascular abnormalities–including pulmonary embolism (PE), cardiac morphology, and vascular congestion. Secondary objectives include the predictive value of cardiovascular abnormalities in terms of disease severity and fatal outcome and the association of lung inflammation with vascular abnormalities at the segmental level. New quantitative approaches derived from CT imaging are developed and evaluated in this study. Patients with and without vascular abnormalities will be compared, which is supposed to provide insights into the prognostic role and potential impact of such signs on treatment strategy. Results are expected to enable the development of an integrative score combining both clinical data and imaging findings to predict outcomes.

show abstract

“… 1 At the time our article was published, there was a lack of scientific data that correlated chest CT imaging to postmortem pathologic findings in this disease. Recently, Henkel et al 2 published a series of 14 patients who died of COVID-19, in whom a morphologic comparison of antemortem chest CT scans with postmortem gross findings and histopathologic findings was performed. Five of 14 patients in their study also underwent contrast-enhanced CT imaging.…”

mentioning

confidence: 99%