Lethal quercetin-digoxin interaction in pigs

Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2

“…Increasing evidence from recent animal and human studies has indicated that flavonoids may interact with many clinically important drugs, causing favorable or adverse pharmacokinetic interactions (Kruijtzer , 2002;Choi et al, 2004;Wang et al, 2004). However, the mechanisms underlying most of these reported interactions are largely related to the modulation of drug-metabolizing enzymes and/or Pglycoprotein (Harris et al, 2003;Sparreboom et al, 2004).…”

“…In some cases, these flavonoid-drug interactions can be serious or even life-threatening. This is true especially when flavonoids or dietary supplements are used concomitantly with narrow therapeutic index drugs, such as digoxin (Wang et al, 2004). On the other hand, coadministration of drug candidates with flavonoids, which are inhibitors of known drug transporters and metabolizing enzymes, may represent a strategy to improve the bioavailability of the coadministered drug.…”

Bioavailability enhancers of herbal origin: An overview

“…Quercetin has exhibited a wide range of beneficial biological activities including antioxidant, radical scavenging, anti-inflammatory, anti-atherosclerotic, anti-tumoral and anti-viral effects [35] . Quercetin has been shown to increase bioavailability, blood levels and efficacy of a number of drugs including diltiazem, digoxin and epigallocatechin gallaate [36][37][38][39] .…”

Pharmacokinetic Interaction between the Flavonoid Luteolin and γ-Hydroxybutyrate in Rats: Potential Involvement of Monocarboxylate Transporters

“…These interactions, in some cases, can cause serious or life-threatening adverse effects, especially when flavonoids are used together with narrow therapeutic index drugs (12). On the other hand, flavonoids have been shown to be able to improve the bioavailability of the coadministered drugs, resulting in beneficial flavonoid-drug interactions (11,13).…”