2007
DOI: 10.1016/j.forsciint.2005.12.027
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Lethal self administration of propofol (Diprivan)

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Cited by 66 publications
(13 citation statements)
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“…However, Korean data on propofol in the high risk group are still limited. Although misuse of propofol and associated death have been reported [30-32], this became a social issue in Korea recently. Thus, we were prompted to further evaluate the safety of propofol in cirrhotic patients who are thought to be vulnerable to sedatives or anesthetic drugs.…”
Section: Discussionmentioning
confidence: 99%
“…However, Korean data on propofol in the high risk group are still limited. Although misuse of propofol and associated death have been reported [30-32], this became a social issue in Korea recently. Thus, we were prompted to further evaluate the safety of propofol in cirrhotic patients who are thought to be vulnerable to sedatives or anesthetic drugs.…”
Section: Discussionmentioning
confidence: 99%
“…2 Several case reports have described propofol abuse in nurses, anesthesiologists, and laypersons. 3 In a study in which the rewarding effects of propofol were assessed in humans, using a discrete-trials choice procedure, normal healthy volunteers without a drug abuse history ( n = 12) were exposed in a blind fashion to acute bolus injections of 0.6 mg/kg of propofol twice and to a similar volume of Intralipid® twice. Then, for the next 3 sessions, subjects chose which drug (identified by a color code) they wished to receive.…”
mentioning
confidence: 99%
“…Although propofol and PPFG have been detected in several matrices including blood, urine, and hair [24], as well as in fingernails by our laboratory group (data not shown), a 28 day window of detection in urine, as is shown here, would be more than sufficient as the most cost-effective and efficient method of screening. Patterns of addiction seen with propofol indicate abuse of the compound involves multiple injections on frequent occasions [10][11][12][13][14]20,23], and it is highly unlikely the urinary PPFG profile for such behavior would show faster terminal elimination from the body than is seen in both the anesthetic and oral ingestion datasets presented here (Figures 1 and 2).…”
Section: Propofol Vs Ppfg For the Detection Of Propofol Use And Abusementioning
confidence: 89%
“…Despite its narrow therapeutic window [7] propofol has a high potential for abuse among healthcare professionals with access to propofol stocks [18], and propofol abuse has become a concern in the healthcare community [6]. The addictive nature of propofol has been previously demonstrated [19,20], and several fatalities due to acute intoxication without respiratory monitoring have occurred [10][11][12][13][14]. Data suggests that second-hand exposure to propofol is high in hospital operating rooms and may cause sensitization from chronic exposure, potentially leading to an increased risk for use and abuse by anesthesia and surgical professionals [21,22].…”
Section: Propofol Vs Ppfg For the Detection Of Propofol Use And Abusementioning
confidence: 99%
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