2019
DOI: 10.1186/s12958-018-0443-x
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Letrozole-associated controlled ovarian hyperstimulation in breast cancer patients versus conventional controlled ovarian hyperstimulation in infertile patients: assessment of oocyte quality related biomarkers

Abstract: BackgroundFertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of Let-COH on the follicular microenvironment has been poorly investigated, although a high androgen/estrogen ratio was previously associated with low oocyte quality.MethodsIn this prospective study, follicular fluid (FF) steroid levels (estradiol, testosterone, progesterone) and cumulus cell (CC) g… Show more

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Cited by 27 publications
(32 citation statements)
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“…The search strategy returned 625 records: after applying the inclusion and exclusion criteria, 15 records were potentially eligible for this meta-analysis ( Figure 1 ). Among them, three records were excluded because they referred to the same study: in two cases [Goldrat et al ( 38 ) vs. Goldrat et al ( 34 ) and Cakman et al ( 39 ) vs. Quinn et al ( 36 )], the article with the most updated data was selected ( 34 , 36 ); for the other case [Haas et al ( 24 ) vs. Haas et al ( 40 )], the least recent paper was included because of a larger sample size and the reporting of endpoints considered in the present meta-analysis ( 24 ). One article was excluded because it did not provide the required data for statistical analysis ( 41 ).…”
Section: Resultsmentioning
confidence: 99%
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“…The search strategy returned 625 records: after applying the inclusion and exclusion criteria, 15 records were potentially eligible for this meta-analysis ( Figure 1 ). Among them, three records were excluded because they referred to the same study: in two cases [Goldrat et al ( 38 ) vs. Goldrat et al ( 34 ) and Cakman et al ( 39 ) vs. Quinn et al ( 36 )], the article with the most updated data was selected ( 34 , 36 ); for the other case [Haas et al ( 24 ) vs. Haas et al ( 40 )], the least recent paper was included because of a larger sample size and the reporting of endpoints considered in the present meta-analysis ( 24 ). One article was excluded because it did not provide the required data for statistical analysis ( 41 ).…”
Section: Resultsmentioning
confidence: 99%
“…Six studies were conducted in cancer patients only ( 35 37 , 42 , 43 , 45 ); one study in infertile patients only ( 24 ). COS with letrozole in cancer patients was compared to COS without letrozole in infertile controls in two studies ( 29 , 34 ), to COS without letrozole in healthy elective fertility preservation patients in another study ( 33 ), and to both cancer patients and healthy elective fertility preservation patients in another study ( 44 ).…”
Section: Resultsmentioning
confidence: 99%
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