Letrozole for patients with polycystic ovary syndrome

Guang, Hui-Juan; Li, Feng; Shi, Jun

doi:10.1097/md.0000000000013038

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…Our study followed pregnancy outcomes, and no fetal anomalies were documented in our study group, supporting the safety of letrozole [38][39][40][41][42]. Our study patients did not demonstrate any significant differences in pregnancy complications in either the aFET or the letrozole group.…”

Section: Afet Vs Ovu-fetsupporting

confidence: 72%

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Aslih

Dorzia

Atzmon

et al. 2021

JCM

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This study evaluated which endometrial preparation protocol in frozen embryo transfer (FET) cycles provides the best results for polycystic ovarian syndrome (PCOS) patients and the general population. This retrospective study of 634 FET cycles was conducted 2016–2018. Cycles were divided into Group A: Artificial endometrial preparations for FET (aFET; n = 348), Group B: Ovulatory cycle (n = 286) to compare two methods of endometrial preparation for FET. Artificial endometrial preparation with exogenous estrogen and progesterone versus natural ovulation cycles, modified natural cycles using hCG for the final triggering and letrozole-induced ovulation with hCG. Anovulatory patients were analyzed separately. Anovulatory PCOS patients had significantly higher pregnancy rates with letrozole treatment compared with aFET cycles (44% vs. 22.5%; p = 0.044). For the entire cohort, ovulatory cycles and aFET were similar in terms of patient characteristics, demographics, infertility causes, treatment protocols and number of embryos transferred. Although the mean ESHRE score of the transferred embryos was higher in the aFET group, we found higher clinical pregnancy rate in the ovulatory cycle FET (41.3% vs. 27.3%, p < 0.0001). A better pregnancy rate was found after ovulatory cycle FET. In the ovulatory cycles, the outcome of letrozole-induced and non-induced cycles were comparable. PCOS patients, as well as the general population, may benefit from ovulation induced FET cycles, with significantly better outcomes in FET in ovulatory cycles.

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Section: Afet Vs Ovu-fetsupporting

confidence: 72%

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Aslih

Dorzia

Atzmon

et al. 2021

JCM

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“…[8] Literature suggests that treatment with various pharmaceutical drugs such as metformin, clomiphene citrate, letrozole, antiandrogen drugs and gonadotropin are useful but have several side effects. [9,10,11] Therefore, it becomes essential to explore alternative drugs for the management of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Sitagliptin recuperates oxidative stress and inflammatory cytokine expression in ovary of PCOS rats

Carani

Nanda²

2019

J. Drug Delivery Ther.

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Abstract Introduction: Polycystic ovary syndrome (PCOS) is an endocrine, reproductive and metabolic disorder and a major cause of infertility in women. Testosterone propionate (TP) is used to induce PCOS in rats. High calorie diet causes metabolic changes, oxidative stress and PCOS. Sitagliptin (STG) is an inhibitor of dipeptide peptidase (DPP) 4 enzyme used in the treatment of type 2 diabetes. Objective: The aim of the study is to investigate the effect of high fat, high fructose diet (HFFD) on TP induced PCOS rats and the role of STG on oxidative stress and inflammation in PCOS. Materials and methods: PCOS was induced by administration of TP to normal pellet and HFFD fed rats for 43 days. STG (i.p.) was given for the last 15 days to both groups of rats. Vaginal smear, parameters of oxidative stress, antioxidants and inflammation (TNF-α and IL-6) in ovary were analyzed. Results: Vaginal smear from TP rats consisted of persistent leucocytes, a characteristic of PCOS. All the TP administered rats registered significanty elevated levels of glucose, lipids, oxidative stress and inflammatory markers, and reduced levels of antioxidants compared to CON rats. STG treatment to PCOS rats reduced hyperglycemia and hyperlipidemia, oxidative stress and inflammation and improved estrus cycle. Conclusion: High energy diet aggravated TP-induced changes in oxidative stress and inflammatory cytokines in ovary. STG recuperated the changes induced by TP, suggesting that STG holds potential for PCOS management.

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“…One of the major causes of female infertility is the presence of cysts in the ovary, similar to that seen in polycystic ovarian syndrome. A cyst is a fluid-filled follicle that cannot develop into a functional egg and letrozole has been used to improve fertility in such cases [ 20 ]. In this study, the fertility-impaired group had a significantly higher number of cysts compared to the healthy group and treatment with PJSO reversed cyst formation as well as inflammation seen in the ovary.…”

Section: Discussionmentioning

confidence: 99%

“…Oligoasthenozoospermia, reduced sperm count and sperm motility, was seen in the zebrafish ENU mutants in this study. Anti-estrogens such as clomiphene have been shown to increase the secretion of gonadotropin-releasing hormone (GnRH) and thus, have been prescribed for empirical treatment of idiopathic male infertility [ 19 , 20 ]. Treatment with PJSO showed a significant increase in the number of spermatids and a reduction in the number of spermatogonia cells.…”

Section: Discussionmentioning

confidence: 99%

Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model

et al. 2021

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Putrajeevak (Putranjiva roxburghii Wall.; synonym Drypetes roxburghii (Wall.) Hurus) seeds have been used since ancient times in the treatment of infertility in the Ayurvedic system of medicine in India. In this study, the oil component of Putrajeevak seeds (PJSO) was extracted using the supercritical fluid extraction (SCFE) method using liquid CO2 and the constituents were analyzed using gas chromatography-flame ionized detectorand high-performance thin-layer chromatography. PJSO contained trace amounts of β-sitosterol with oleic and linoleic acids as the major fatty acid constituents. Male and female zebrafish were mutagenized with N-ethyl-N-nitrosourea (ENU) and fish that produced less than 20 viable embryos were selected for the study. SCFE oil extracts from the P. roxburghii seeds were used in this study to reverse fertility impairment. The mutant fish were fed with PJSO for a period of 14 days and the rates of fertility, conception, and fecundity were determined with wild-type healthy fish as a breeding partner. Treatment with PJSO increased the ovarian follicle count as well as the number of mature eggs, while reducing the number of ovarian cysts. Sperm count as well as sperm motility were greatly enhanced in the ENU-mutagenized male zebrafish when treated with PJSO. The results obtained in this study demonstrate the effectiveness of P. roxburghii seed oil in reversing impaired fertility in both male and female zebrafish models.

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Letrozole for patients with polycystic ovary syndrome

Cited by 18 publications

References 33 publications

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Ovulatory-Based FET Cycles May Achieve Higher Pregnancy Rates in the General Population and among Anovulatory Women

Sitagliptin recuperates oxidative stress and inflammatory cytokine expression in ovary of PCOS rats

Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model

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